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dc.contributorKim, Eui-Sooen_US
dc.contributorElbeltagy, Ahmed R.en_US
dc.contributorAdel M. Aboul-Naga, Adelen_US
dc.contributorRischkowsky, Barbaraen_US
dc.contributorRothschild, Max F.en_US
dc.creatorMwacharo, Joramen_US
dc.identifier.citationJoram Mwacharo, Eui-Soo Kim, Ahmed R. Elbeltagy, Adel Adel M. Aboul-Naga, Barbara Rischkowsky, Max F. Rothschild. (15/12/2017). Genomic footprints of dryland stress adaptation in Egyptian fattail sheep and their divergence from East African and western Asia cohorts. Scientific Reports, 7.en_US
dc.description.abstractAfrican indigenous sheep are classified as fat-tail, thin-tail and fat-rump hair sheep. The fat-tail are well adapted to dryland environments, but little is known on their genome profiles. We analyzed patterns of genomic variation by genotyping, with the Ovine SNP50K microarray, 394 individuals from five populations of fat-tail sheep from a desert environment in Egypt. Comparative inferences with other East African and western Asia fat-tail and European sheep, reveal at least two phylogeographically distinct genepools of fat-tail sheep in Africa that differ from the European genepool, suggesting separate evolutionary and breeding history. We identified 24 candidate selection sweep regions, spanning 172 potentially novel and known genes, which are enriched with genes underpinning dryland adaptation physiology. In particular, we found selection sweeps spanning genes and/or pathways associated with metabolism; response to stress, ultraviolet radiation, oxidative stress and DNA damage repair; activation of immune response; regulation of reproduction, organ function and development, body size and morphology, skin and hair pigmentation, and keratinization. Our findings provide insights on the complexity of genome architecture regarding dryland stress adaptation in the fat-tail sheep and showcase the indigenous stocks as appropriate genotypes for adaptation planning to sustain livestock production and human livelihoods, under future climates.en_US
dc.publisherNature Research (part of Springer Nature) (Fully open access journals)en_US
dc.sourceScientific Reports;7,(2017)en_US
dc.subjectgenomic footprinten_US
dc.titleGenomic footprints of dryland stress adaptation in Egyptian fattail sheep and their divergence from East African and western Asia cohortsen_US
dc.typeJournal Articleen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.creator.idRischkowsky, Barbara: 0000-0002-0035-471Xen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerIowa State University, College of Agriculture and Life Sciences - IASTATE-CALSen_US
cg.contributor.centerAgricultural Economics Research Institute - AERIen_US
cg.contributor.centerAgricultural Research Center, Animal Production Research Institute - ARC - APRIen_US
cg.contributor.centerIowa State University - IASTATEen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionNorthern Africaen_US
cg.isijournalISI Journalen_US
dc.identifier.statusOpen accessen_US
cg.journalScientific Reportsen_US

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