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dc.contributorAkbar, Fazalen_US
dc.contributorIqbal, Zafaren_US
dc.contributorAmrao, Luqmanen_US
dc.contributorAmin, Imranen_US
dc.contributorSaeed, Muhammaden_US
dc.contributorMansoor, Shahiden_US
dc.creatorBriddon, Rob W.en_US
dc.identifier.citationRob W. Briddon, Fazal Akbar, Zafar Iqbal, Luqman Amrao, Imran Amin, Muhammad Saeed, Shahid Mansoor. (24/6/2014). Effects of genetic changes to the begomovirus/betasatellite complex causing cotton leaf curl disease in South Asia post-resistance breaking. Virus Research, 156, pp. 114-119.en_US
dc.description.abstractCotton leaf curl disease (CLCuD) has been a problem for cotton production across Pakistan and north-eastern India since the early 1990s. The appearance of the disease has been attributed to the introduction, and near monoculture of highly susceptible cotton varieties. During the intervening period the genetic make-up of the virus(es) causing the disease has changed dramatically. The most prominent of these changes has been in response to the introduction of CLCuD-resistant cotton varieties in the late 1990s, which provided a brief respite from the losses due to the disease. During the 1990s the disease was shown to be caused by multiple begomoviruses and a single, disease-specific betasatellite. Post-resistance breaking the complex encompassed only a single begomovirus, Cotton leaf curl Burewala virus (CLCuBuV), and a recombinant version of the betasatellite. Surprisingly CLCuBuV lacks an intact transcriptional-activator protein (TrAP) gene. The TrAP gene is found in all begomoviruses and encodes a product of ∼134 amino acids that is important in virus–host interactions; being a suppressor of post-transcriptional gene silencing (host defence) and a transcription factor that modulates host gene expression, including microRNA genes. Recent studies have highlighted the differences between CLCuBuV and the earlier viruses that are part of on-going efforts to define the molecular basis for resistance breaking in cotton.en_US
dc.publisherElsevier (12 months)en_US
dc.sourceVirus Research;156,(2013) Pagination 114,119en_US
dc.subjectcotton leaf curl diseaseen_US
dc.subjectresistance breakingen_US
dc.titleEffects of genetic changes to the begomovirus/betasatellite complex causing cotton leaf curl disease in South Asia post-resistance breakingen_US
dc.typeJournal Articleen_US
cg.contributor.centerNational Institute for Biotechnology & Genetic Engineering - NIBGEen_US
cg.contributor.centerUniversity of Agriculture, Faisalabad - UAFen_US
cg.contributor.funderUnited States Department of Agriculture - USDAen_US
cg.contributor.projectImproving Resistance to Cotton Leaf Curl Virus (CLCuV) and Supporting Cotton Best Management Practices for Small Farmersen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionSouthern Asiaen_US
dc.identifier.statusTimeless limited accessen_US

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