Show simple item record

dc.contributorJabri, Mohamed-Amineen_US
dc.contributorAlimi, Dhouhaen_US
dc.contributorRekik, Mouraden_US
dc.contributorAkkari, Hafidhen_US
dc.creatorHajaji, Soumayaen_US
dc.identifier.citationSoumaya Hajaji, Mohamed-Amine Jabri, Dhouha Alimi, Mourad Rekik, Hafidh Akkari. (1/3/2019). Chamomile Methanolic Extract Mitigates Small Bowel Inflammation and ROS Overload Related to the Intestinal Nematodes Infection in Mice. Acta Parasitologica, 64 (1), pp. 152-161.en_US
dc.description.abstractBackground Chamomile (Matricaria recutita L.) is a plant which has been reported to be effective in treating several parasitic and digestive diseases. The present study was conducted to evaluate the anthelmintic activity of chamomile methanolic extract (CME). Methods In vitro, the anthelmintic activities of CME were investigated on the L3 larvae of Heligmosomoides polygyrus in comparison to albendazole. In vivo, Swiss albino mice were infected with infective third (L3) larval stage of H. polygyrus by intragastric administration. Moreover, the effect of CME and albendazole on worm eggs, adult worms, serum cytokine production, and oxidative stress was studied. Results All used doses of CME showed a potent anthelmintic activity both in vitro and in vivo and the effect being similar to treatment with albendazole. Moreover, H. polygyrus infestation was accompanied by an intestinal oxidative stress status characterized by an increased lipoperoxidation, a depletion of antioxidant enzyme activity, as well as an overload of hydrogen peroxide. We have also recorded an increase of pro-inflammatory mediator (TNF-α, IL-6, and IL-1β) levels after treatment with CME (14 ± 0.8; 41 ± 2; 58 ± 4 pg/mg protein, respectively, with the concentration 800 mg/kg, body weight) when compared with infected control mice (20 ± 1; 59 ± 2, and 83 ± 4 pg/mg protein, respectively). However, extract treatment alleviated all the deleterious effects associated with H. polygyrus infection. Conclusion These findings suggest that CME can be used in the control of gastrointestinal helminthiasis and associated oxidative stress.en_US
dc.sourceActa Parasitologica;64,(2019) Pagination 152-161en_US
dc.titleChamomile Methanolic Extract Mitigates Small Bowel Inflammation and ROS Overload Related to the Intestinal Nematodes Infection in Miceen_US
dc.typeJournal Articleen_US
cg.creator.idRekik, Mourad: 0000-0001-7455-2017en_US
cg.subject.agrovocheligmosomoides polygyrusen_US
cg.subject.agrovocoxidative stressen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerManouba University, National School of Veterinary Medicine of Sidi Thabet - ENMVen_US
cg.contributor.centerManouba University - UMAen_US
cg.contributor.centerUniversity of Carthage, Faculty of Science - UCAR Tunis - FSen_US
cg.contributor.centerUniversity of Jendouba, Higher Institute of Biotechnology of Beja - UJ - ISBBen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionNorthern Africaen_US
cg.isijournalISI Journalen_US
dc.identifier.statusTimeless limited accessen_US
cg.journalActa Parasitologicaen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

DSpace software copyright © 2002-2016  DuraSpace
MELSpace content providers and partners accept no liability to any consequence resulting from use of the content or data made available in this repository. Users of this content assume full responsibility for compliance with all relevant national or international regulations and legislation.
Theme by 
Atmire NV