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dc.contributorGebreselasse, Haileen_US
dc.contributorXu, Lingyangen_US
dc.contributorIslam, Rabiulen_US
dc.contributorRekik, Mouraden_US
dc.contributorJianlin, Hanen_US
dc.contributorZhao, Qianjunen_US
dc.contributorMwacharo, Joramen_US
dc.contributorMa, Yuehuien_US
dc.creatorAbied, Adam Abdallhaen_US
dc.identifier.citationAdam Abdallha Abied, Haile Gebreselasse, Lingyang Xu, Rabiul Islam, Mourad Rekik, Han Jianlin, Qianjun Zhao, Joram Mwacharo, Yuehui Ma. (15/11/2019). Assessing genome architecture and signatures of selection in the Sudan thin-tailed Desert sheep. Frontiers.en_US
dc.description.abstractThin-tail sheep are the most ancient in Africa. They are found in hot arid environments in Egypt, Morocco and Sudan and are the only type found in sub-humid and humid environments in West and Central Africa. Compared to the fat-tail sheep, their genome profile remains poorly investigated. Using 600K SNP genotypes, the genome diversity, structure and dynamics of five ecotypes of Sudan thin-tail Desert sheep were investigated. Genotypes from four breeds of Chinese fat-tail sheep were included in the study for comparative purposes. The analysis revealed moderate genetic diversity in the five Sudan thin-tail Desert sheep ecotypes. PCA, phylogenetic analysis and STRUCTURE (K = 5) revealed AL-Ahamda to be slightly genetically differentiated. Unexpectedly, a few individuals of Kabashi ecotype had a unique genetic background at K = 2. Selection signature analysis, contrasting Sudan thin-tail Desert and Chinese fat-tail Tan sheep, identified 41 candidate regions, spanning 72 potentially novel and known genes which were associated with response to heat stress (HSPA5, DNAJB14, YTHDF1), influencing lifespan (GAK, CPLX1), growth regulation (CSMD1, FGFR3, BRCA1), body weight and height variation (DIS3L2, TP53), fat deposition and tail growth (NPR2, ADD1, SNORA73), metabolic pathways (ATP1B2, G6BC, U2, STRT3, MYT3, GLI1), production (FGF9, LATS2), and reproduction (TET2, H2AFZ, OVOL1, SPAG4, EEF1A2, NPTX1, MELK, FGF2, PPP2R5D, MAPKAP1, LGR5), prolificacy (PDE6B, XRN2, EFNB3), immunity (COMMD4, ADPP1, FGB, SIGLEC1, ELF4A1) and disease resistance and inflammatory responses (POLR2A, TNFSF13, CD68, SAT2, GAA, PPT2, RABEPK, SCAI, LHX2). Our findings offer insights on the genome architecture of Sudan thin-tail Desert sheep. They call for further investigations to determine whether the observed genome structure characterize other African thin-tail sheep.en_US
dc.publisherUniversity of Nebraska Pressen_US
dc.subjectgenetic diversityen_US
dc.subjectselection sweepen_US
dc.subjectovine hd snpen_US
dc.titleAssessing genome architecture and signatures of selection in the Sudan thin-tailed Desert sheepen_US
dc.typeJournal Articleen_US
cg.creator.idRekik, Mourad: 0000-0001-7455-2017en_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.contributor.centerChinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IASen_US
cg.contributor.centerChinese Academy of Agricultural Sciences - CAASen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionNorthern Africaen_US
dc.identifier.statusTimeless limited accessen_US

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