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dc.contributorBagadi, Alnooren_US
dc.contributorBordbar, Farhaden_US
dc.contributorPu, Yabinen_US
dc.contributorAugustino, Serafinoen_US
dc.contributorXue, Xianglanen_US
dc.contributorXing, Fengen_US
dc.contributorGebreselassie, Gebremedhinen_US
dc.contributorJianlin, Hanen_US
dc.contributorMwacharo, Joramen_US
dc.contributorMa, Yuehuien_US
dc.contributorZhao, Qianjunen_US
dc.creatorAbied, Adam Abdallhaen_US
dc.identifier.citationAdam Abdallha Abied, Alnoor Bagadi, Farhad Bordbar, Yabin Pu, Serafino Augustino, Xianglan Xue, Feng Xing, Gebremedhin Gebreselassie, Han Jianlin, Joram Mwacharo, Yuehui Ma, Qianjun Zhao. (30/4/2020). Genomic Diversity, Population Structure, and Signature of Selection in Five Chinese Native Sheep Breeds Adapted to Extreme Environments. Genes, 11 (5).en_US
dc.description.abstractThrough long term natural and artificial selection, domestic sheep (Ovis aries) have become adapted to a diverse range of agro-ecological environments and display multiple phenotypic traits. Characterization of diversity and selection signature is essential for genetic improvement, understanding of environmental adaptation, as well as utilization and conservation of sheep genetic resources. Here, we aimed to assess genomic diversity, population structure, and genomic selection among five Chinese native sheep breeds using 600K high density SNP genotypes. A total of 96 animals of the five breeds were selected from different geographical locations with extremely dry or humid conditions. We found a high proportion of informative SNPs, ranging from 93.3% in Yabuyi to 95.5% in Wadi, Hu, and Hetian sheep. The average pairwise population differentiation (FST) between the breeds was 0.048%, ranging from 0.022% to 0.054%, indicating their low to moderate differentiation. PCA, ADMIXTURE, and phylogenetic tree analyses revealed a clustering pattern of the five Chinese sheep breeds according to their geographical distribution, tail type, coat color, body size, and breeding history. The genomic regions under putative selection identified by FST and XP-EHH approaches frequently overlapped across the breeds, and spanned genes associated with adaptation to extremely dry or humid environments, innate and adaptive immune responses, and growth, wool, milk, and reproduction traits. The present study offers novel insight into genomic adaptation to dry and humid climates in sheep among other domestic animals and provides a valuable resource for further investigation. Moreover, it contributes useful information to sustainable utilization and conservation of sheep genetic resources.en_US
dc.subjectselection sweepen_US
dc.subjecthigh density snpsen_US
dc.subjectgenomic diversityen_US
dc.subjectchinese sheepen_US
dc.titleGenomic Diversity, Population Structure, and Signature of Selection in Five Chinese Native Sheep Breeds Adapted to Extreme Environmentsen_US
dc.typeJournal Articleen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.contributor.centerChinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IASen_US
cg.contributor.centerAgricultural Research Corporation, Dry Lands Research Center - ARC - DLRCen_US
cg.contributor.centerChina Agricultural University, College of Animal Science and Technology - CAU China - CoASATen_US
cg.contributor.centerTalimu University, College of Animal Science - TU - CoASen_US
cg.contributor.centerInternational Livestock Research Institute - ILRIen_US
cg.contributor.centerChinese Academy of Agricultural Sciences - CAASen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.projectCommunication and Documentation Information Services (CODIS)en_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
dc.identifier.statusOpen accessen_US

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