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dc.contributorXue, Xianglanen_US
dc.contributorLiu, Yueen_US
dc.contributorAbied, Adam Abdallhaen_US
dc.contributorDing, Yangyangen_US
dc.contributorZhao, Shengguoen_US
dc.contributorWang, Wenqiangen_US
dc.contributorMa, Liqingen_US
dc.contributorGuo, Jijunen_US
dc.contributorGuan, Weijunen_US
dc.contributorPu, Yabinen_US
dc.contributorMwachar, Joram M.en_US
dc.contributorJianlin, Hanen_US
dc.contributorMa, Yuehuien_US
dc.contributorZhao, Qianjunen_US
dc.creatorZhang, Yingyueen_US
dc.identifier.citationYingyue Zhang, Xianglan Xue, Yue Liu, Adam Abdallha Abied, Yangyang Ding, Shengguo Zhao, Wenqiang Wang, Liqing Ma, Jijun Guo, Weijun Guan, Yabin Pu, Joram M. Mwachar, Han Jianlin, Yuehui Ma, Qianjun Zhao. (28/1/2021). Genome‑wide comparative analyses reveal selection signatures underlying adaptation and production in Tibetan and Poll Dorset sheep. Scientific Reports, 11.en_US
dc.description.abstractThe identification of genome-wide selection signatures can provide insights on the mechanisms of natural and/or artificial selection and uncover genes related to biological functions and/or phenotypes. Tibetan sheep are an important livestock in Tibet, providing meat and wool for Tibetans who are renown for breeding livestock that adapt well to high altitudes. Using whole-genome sequences with an effective sequencing depth of 5×, we investigated the genomic diversity and structure and, identified selection signatures of White Tibetan, Oula and Poll Dorset sheep. We obtained 30,163,679 Single Nucleotide Polymorphisms (SNPs) and 5,388,372 indels benchmarked against the ovine Oar_v4.0 genome assembly. Next, using FST, ZHp and XP-EHH approaches, we identified selection signatures spanning a set of candidate genes, including HIF1A, CAPN3, PRKAA1, RXFP2, TRHR and HOXA10 that are associated with pathways and GO categories putatively related to hypoxia responses, meat traits and disease resistance. Candidate genes and GO terms associated with coat color were also identified. Finally, quantification of blood physiological parameters, revealed higher levels of mean corpuscular hemoglobin measurement and mean corpuscular hemoglobin concentration in Tibetan sheep compared with Poll Dorset, suggesting a greater oxygen-carrying capacity in the Tibetan sheep and thus better adaptation to high-altitude hypoxia. In conclusion, this study provides a greater understanding of genome diversity and variations associated with adaptive and production traits in sheep.en_US
dc.publisherNATURE RESEARCHen_US
dc.sourceScientific Reports;11,(2021)en_US
dc.subjectpoll dorset sheepen_US
dc.subjectqinghai white tibetan sheepen_US
dc.subjectoula sheepen_US
dc.titleGenome‑wide comparative analyses reveal selection signatures underlying adaptation and production in Tibetan and Poll Dorset sheepen_US
dc.typeJournal Articleen_US
cg.subject.agrovocselection signaturesen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerChinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IASen_US
cg.contributor.centerCAAS‑ILRI Joint Laboratory On Livestock and Forage Genetic Resources, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences (CAAS)en_US
cg.contributor.centerQinghai Academy of Animal Science and Veterinary Medicineen_US
cg.contributor.centerAnimal Husbandry and Veterinary Service of Qinghaien_US
cg.contributor.centerGansu Agricultural University, College of Animal Science and Technology - GAU - Coasten_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.projectCommunication and Documentation Information Services (CODIS)en_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionEastern Asiaen_US
cg.isijournalISI Journalen_US
dc.identifier.statusOpen accessen_US
cg.journalScientific Reportsen_US

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