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dc.contributorRouatbi, Mariemen_US
dc.contributorGharbi, Mohameden_US
dc.contributorRekik, Mouraden_US
dc.contributorHaile, Aynalemen_US
dc.contributorRischkowsky, Barbaraen_US
dc.contributorMwacharo, Joramen_US
dc.creatorAhbara, Abulgasimen_US
dc.identifier.citationAbulgasim Ahbara, Mariem Rouatbi, Mohamed Gharbi, Mourad Rekik, Aynalem Haile, Barbara Rischkowsky, Joram Mwacharo. (29/4/2021). Genome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheep. Scientific Reports, 11, pp. 1-16.en_US
dc.description.abstractGastrointestinal nematode (GIN) infections have negative impacts on animal health, welfare and production. Information from molecular studies can highlight the underlying genetic mechanisms that enhance host resistance to GIN. However, such information often lacks for traditionally managed indigenous livestock. Here, we analysed 600 K single nucleotide polymorphism genotypes of GIN infected and non-infected traditionally managed autochthonous Tunisian sheep grazing communal natural pastures. Population structure analysis did not find genetic differentiation that is consistent with infection status. However, by contrasting the infected versus non-infected cohorts using ROH, LR-GWAS, FST and XP-EHH, we identified 35 candidate regions that overlapped between at least two methods. Nineteen regions harboured QTLs for parasite resistance, immune capacity and disease susceptibility and, ten regions harboured QTLs for production (growth) and meat and carcass (fatness and anatomy) traits. The analysis also revealed candidate regions spanning genes enhancing innate immune defence (SLC22A4, SLC22A5, IL-4, IL-13), intestinal wound healing/repair (IL-4, VIL1, CXCR1, CXCR2) and GIN expulsion (IL-4, IL-13). Our results suggest that traditionally managed indigenous sheep have evolved multiple strategies that evoke and enhance GIN resistance and developmental stability. They confirm the importance of obtaining information from indigenous sheep to investigate genomic regions of functional significance in understanding the architecture of GIN resistance.en_US
dc.publisherNATURE RESEARCHen_US
dc.sourceScientific Reports;11,(2021) Pagination 1,16en_US
dc.subjectagricultural geneticsen_US
dc.titleGenome-wide insights on gastrointestinal nematode resistance in autochthonous Tunisian sheepen_US
dc.typeJournal Articleen_US
cg.creator.idRekik, Mourad: 0000-0001-7455-2017en_US
cg.creator.idHaile, Aynalem: 0000-0001-5914-0487en_US
cg.creator.idRischkowsky, Barbara: 0000-0002-0035-471Xen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.contributor.centerMisurata Universityen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerManouba University, National School of Veterinary Medicine of Sidi Thabet - ENMVen_US
cg.contributor.centerManouba University - UMAen_US
cg.contributor.centerCenter for Tropical Livestock Genetics and Health - CLTGHen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionNorthern Africaen_US
dc.identifier.statusOpen accessen_US

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