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dc.contributorRobert, Christelleen_US
dc.contributorAhbara, Abulgasimen_US
dc.contributorSalavati, Mazdaken_US
dc.contributorAbebe, Ayeleen_US
dc.contributorBelew, Adebabayen_US
dc.contributorWragg, Daviden_US
dc.contributorFriedrich, Julianeen_US
dc.contributorVasoya, Deepalien_US
dc.contributorA. Hume, Daviden_US
dc.contributorDjikeng, Appolinaireen_US
dc.contributorWatson, Micken_US
dc.contributorPrendergast, James G.Den_US
dc.contributorHanotte, Olivieren_US
dc.contributorMwacharo, Joramen_US
dc.contributorClark, Emily Len_US
dc.creatorWiener, Pamelaen_US
dc.identifier.citationPamela Wiener, Christelle Robert, Abulgasim Ahbara, Mazdak Salavati, Ayele Abebe, Adebabay Belew, David Wragg, Juliane Friedrich, Deepali Vasoya, David A. Hume, Appolinaire Djikeng, Mick Watson, James G. D Prendergast, Olivier Hanotte, Joram Mwacharo, Emily L Clark. (27/1/2021). Whole-Genome Sequence Data Suggest Environmental Adaptation of Ethiopian Sheep Populations. Genome Biology and Evolution, 13 (3).en_US
dc.description.abstractGreat progress has been made over recent years in the identification of selection signatures in the genomes of livestock species. This work has primarily been carried out in commercial breeds for which the dominant selection pressures are associated with artificial selection. As agriculture and food security are likely to be strongly affected by climate change, a better understanding of environment-imposed selection on agricultural species is warranted. Ethiopia is an ideal setting to investigate environmental adaptation in livestock due to its wide variation in geo-climatic characteristics and the extensive genetic and phenotypic variation of its livestock. Here, we identified over three million single nucleotide variants across 12 Ethiopian sheep populations and applied landscape genomics approaches to investigate the association between these variants and environmental variables. Our results suggest that environmental adaptation for precipitation-related variables is stronger than that related to altitude or temperature, consistent with large-scale meta-analyses of selection pressure across species. The set of genes showing association with environmental variables was enriched for genes highly expressed in human blood and nerve tissues. There was also evidence of enrichment for genes associated with high-altitude adaptation although no strong association was identified with hypoxia-inducible-factor (HIF) genes. One of the strongest altitude-related signals was for a collagen gene, consistent with previous studies of high-altitude adaptation. Several altitude-associated genes also showed evidence of adaptation with temperature, suggesting a relationship between responses to these environmental factors. These results provide a foundation to investigate further the effects of climatic variables on small ruminant populations.en_US
dc.publisherOxford University Press (OUP)en_US
dc.sourceGenome Biology and Evolution;13,(2021)en_US
dc.titleWhole-Genome Sequence Data Suggest Environmental Adaptation of Ethiopian Sheep Populationsen_US
dc.typeJournal Articleen_US
cg.creator.idHanotte, Olivier: 0000-0002-2877-4767en_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.contributor.centerUniversity of Edinburgh, College of Medicine & Veterinary Medicine, The Roslin Institute - ED - CoM&VM - ROSLINen_US
cg.contributor.centerCenter for Tropical Livestock Genetics and Health - CLTGHen_US
cg.contributor.centerUniversity of Nottingham - UoN UKen_US
cg.contributor.centerMisurata Universityen_US
cg.contributor.centerAmhara Regional Agricultural Research Institute, Debre Birhan Agricultural Research Center - ARARI-DBARCen_US
cg.contributor.centerAmhara Regional Agricultural Research Institute - ARARIen_US
cg.contributor.centerInternational Livestock Research Institute - ILRIen_US
cg.contributor.centerUniversity of Queensland - UQen_US
cg.contributor.centerUniversity of Nottingham, School of Life Sciences - UoN UK - School of Life Sciencesen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerScotland's Rural College - SRUCen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionEastern Africaen_US
dc.identifier.statusOpen accessen_US

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