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dc.contributorXu, Leien_US
dc.contributorW. Sahlu, Bahlibien_US
dc.contributorXing, Fengen_US
dc.contributorAhbara, Abugasimen_US
dc.contributorPu, Yabinen_US
dc.contributorJiang, Linen_US
dc.contributorBerihulay, Haileen_US
dc.contributorIslam, Rabiulen_US
dc.contributorHe, Xiaohongen_US
dc.contributorMwacharo, Joramen_US
dc.contributorZhao, Qianjunen_US
dc.contributorMa, Yuehuien_US
dc.creatorAbied, Adam Abdallhaen_US
dc.date2020-12-09en_US
dc.date.accessioned2021-09-09T23:09:33Z
dc.date.available2021-09-09T23:09:33Z
dc.identifierhttps://mel.cgiar.org/reporting/download/hash/f9bc62e8e9a5bf215c70de67a32dbe6fen_US
dc.identifier.citationAdam Abdallha Abied, Lei Xu, Bahlibi W. Sahlu, Feng Xing, Abugasim Ahbara, Yabin Pu, Lin Jiang, Haile Berihulay, Rabiul Islam, Xiaohong He, Joram Mwacharo, Qianjun Zhao, Yuehui Ma. (9/12/2020). Genome-Wide Analysis Revealed Homozygosity and Demographic History of Five Chinese Sheep Breeds Adapted to Di erent Environments. Genes, 11 (12).en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/13672
dc.description.abstractHomozygosity of long sequence genotypes are a result of parents transmitting identical haplotypes, which can be used to estimate their auto-zygosity. Therefore, we used high-density SNP Chip data to characterize the auto-zygosity of each breed according to the occurrence and distribution of runs of homozygosity (ROH). Subsequently, we identified the genomic regions with high runs of homozygosity frequencies within individuals of each breed. We selected 96 sheep samples from five local Chinese sheep breeds belonging to di erent geographical locations. We identified 3046 ROHs within the study breed individuals, among which the longer segments (>1–5 Mb) were dominant. On average, ROH segments covered about 12% of the genomes; the coverage rate of OAR20 was the lowest and that of OAR2 was the highest. The distribution analysis of runs of homozygosity showed that the detected ROH mainly distributed between >26 and 28 Mb. The Hetian and Hu sheep showed the lowest ROH distribution. The estimation of homozygosity level reflects the history of modern and ancient inbreeding, which may a ect the genomes of Chinese indigenous sheep breeds and indicate that some animals have experienced recent self-pollination events (Yabuyi, Karakul and Wadi). In these sheep breeds, the genomic regions were assumed to be under selection signatures frequently in line with long ROH. These regions included candidate genes associated with disease resistance traits (5S_rRNA), the innate and adaptive immune response (HERC2 and CYFIP1), digestion and metabolism (CENPJ), growth (SPP1), body size and developments (GJB2 and GJA3). This study highlighted new insights into the ROH patterns and provides a basis for future breeding and conservation strategies of Chinese sheep breeds.en_US
dc.formatPDFen_US
dc.languageenen_US
dc.publisherMDPIen_US
dc.rightsCC-BY-4.0en_US
dc.sourceGenes;11,(2020)en_US
dc.subjectsnpsen_US
dc.subjecthigh-densityen_US
dc.subjectminor allele frequencyen_US
dc.subjectSheepen_US
dc.titleGenome-Wide Analysis Revealed Homozygosity and Demographic History of Five Chinese Sheep Breeds Adapted to Di erent Environmentsen_US
dc.typeJournal Articleen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.creator.ID-typeORCIDen_US
cg.subject.agrovocsheepen_US
cg.subject.agrovocinbreedingen_US
cg.contributor.centerAgricultural Research Corporation, Dry Lands Research Center - ARC - DLRCen_US
cg.contributor.centerChinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IASen_US
cg.contributor.centerTalimu University, College of Animal Science - TU - CoASen_US
cg.contributor.centerUniversity of Nottingham, School of Life Sciences - UoN UK - School of Life Sciencesen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionEastern Asiaen_US
cg.coverage.countryCNen_US
cg.contactzhaoqianjun@caas.cnen_US
cg.identifier.doihttps://dx.doi.org/10.3390/genes11121480en_US
dc.identifier.statusOpen accessen_US
mel.project.openhttps://mel.cgiar.org/projects/237en_US
mel.impact-factor4.096en_US


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