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dc.contributorWang, Fengyanen_US
dc.contributorYu, Pingen_US
dc.contributorWang, Xiangyuen_US
dc.contributorHe, Xiaoyunen_US
dc.contributorMwacharo, Joramen_US
dc.contributorPan, Linxiangen_US
dc.contributorChu, Mingxingen_US
dc.creatorDi, Ranen_US
dc.date.accessioned2023-02-22T17:04:44Z
dc.date.available2023-02-22T17:04:44Z
dc.identifierhttps://mel.cgiar.org/reporting/download/hash/4b8d4d8a89924a163c5649a8adc730eaen_US
dc.identifier.citationRan Di, Fengyan Wang, Ping Yu, Xiangyu Wang, Xiaoyun He, Joram Mwacharo, Linxiang Pan, Mingxing Chu. (10/12/2021). Detection of Novel Variations Related to Litter Size in BMP15 Gene of Luzhong Mutton Sheep ( Ovis aries). Animals, 11 (12).en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/68136
dc.description.abstractLitter size is an important economic trait in the mutton sheep industry. BMP15 is one of the key candidate genes for litter size in sheep. In this study, the entire ORF region of BMP15 was sequenced in 154 Luzhong mutton ewes, and the novel variations were determined. The association between polymorphism in BMP15 and litter size was analyzed using a general linear model. Six out of a total of thirteen variations were identified to be novel. Association analysis indicated that four (SNPs ENSOART00000010201.1:c.352+342C>A, c.352+1232T>C, c.352+1165A>G and c.353-2036T>A) were significantly associated with litter size. The joint analysis among three major genes (BMP15, BMPR1B and GDF9) exhibited significant interaction effects in three combinations (FecB and c.352+1232T>C of BMP15; FecB and c.352+1165A>G of BMP15; c.352+342C>A of BMP15 and ENSOART00000014382.1:c.994G>A of GDF9). For the SNPs c.352+1232T>C and c.352+342C>A, the global distribution of allele frequencies showed that the highest variation frequency occurs in Western Europe. In conclusion, the results demonstrated that BMP15 is a major gene for litter size in Luzhong mutton sheep and candidate SNPs associated with litter size were identified.en_US
dc.formatPDFen_US
dc.languageenen_US
dc.publisherMDPIen_US
dc.rightsCC-BY-4.0en_US
dc.sourceAnimals;11,(2021)en_US
dc.subjectbmp15en_US
dc.subjectfecben_US
dc.subjectgdf9en_US
dc.titleDetection of Novel Variations Related to Litter Size in BMP15 Gene of Luzhong Mutton Sheep ( Ovis aries)en_US
dc.typeJournal Articleen_US
dcterms.available2021-12-10en_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.subject.agrovocsheepen_US
cg.subject.agrovoclitter sizeen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerChinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IASen_US
cg.contributor.centerCenter for Tropical Livestock Genetics and Health - CLTGHen_US
cg.contributor.centerShandong Yingtai Agriculture and Animal Husbandry Technology Co., Ltd.en_US
cg.contributor.funderInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.projectCommunication and Documentation Information Services (CODIS)en_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contactmxchu@263.neten_US
cg.identifier.doihttps://dx.doi.org/10.3390/ani11123528en_US
cg.isijournalISI Journalen_US
dc.identifier.statusOpen accessen_US
mel.impact-factor3.231en_US
cg.issn2076-2615en_US
cg.journalAnimalsen_US
cg.issue12en_US
cg.volume11en_US


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