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dc.contributorElbeltagy, Ahmed R.en_US
dc.contributorKim, Eui-Sooen_US
dc.contributorAdel M. Aboul-Naga, Adelen_US
dc.contributorRischkowsky, Barbaraen_US
dc.contributorRothschild, Max F.en_US
dc.creatorMwacharo, Joramen_US
dc.identifier.citationJoram Mwacharo, Ahmed R. Elbeltagy, Eui-Soo Kim, Adel Adel M. Aboul-Naga, Barbara Rischkowsky, Max F. Rothschild. (28/2/2018). Intra-population SNP analysis identifies signatures for grazing stress tolerance in Egyptian local goats. Auckland, New Zealand.en_US
dc.description.abstractThe need to support agricultural industries and human livelihoods in dryland environments using adapted livestock is becoming an unavoidable priority as prospects of global warming become even more evident. Here, using the integrated haplotype score (iHS) approach, we analysed genotype data generated using the caprine 50K Illumina SNP BeadChip from 366 individuals of four local Egyptian desert goat populations to investigate the genetic basis of tolerance to grazing stress. The analysis identified 13 selection sweep regions that spanned 68 genes across eight chromosomes. The strongest selection sweeps were observed on chromosomes 6 and 12 which, spanned 21 and 17 genes, respectively. Though a majority of the identified genes were associated with multiple functions, functional analysis of the 38 genes found in the two strongest candidate regions, revealed the three most significant gene ontology functional term clusters were associated with biological processes of kidney function and development, cellular response to oxidative stress and intra-cellular calcium homeostasis. This suggests that water and mineral homeostasis and the proper maintenance of cellular responses to external stimuli and processes that modulate calcium homeostasis and other signal transduction pathways are key functions in tolerance to grazing stress. Our results could prove useful in genomic selection and identification of genes involved in desert grazing stress tolerance. Key words: adaptation, caprine, genotyping, SNP, selection sweeps,en_US
dc.publisherWorld Congress on Genetics Applied to Livestock Production (WCGALP)en_US
dc.titleIntra-population SNP analysis identifies signatures for grazing stress tolerance in Egyptian local goatsen_US
dc.typeConference Paperen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.creator.idRischkowsky, Barbara: 0000-0002-0035-471Xen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerAgricultural Research Center Egypt - ARC Egypten_US
cg.contributor.centerIowa State University, College of Agriculture and Life Sciences - IASTATE-CALSen_US
cg.contributor.centerAgricultural Research Center, Animal Production Research Institute - ARC - APRIen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionNorthern Africaen_US
dc.identifier.statusOpen accessen_US

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