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dc.contributorMoazami‐Goudarzi, Katayounen_US
dc.contributorAlary, Veroniqueen_US
dc.contributorAraba, Abdelillahen_US
dc.contributorBoujenane, Ismailen_US
dc.contributorBoushaba, Nadjeten_US
dc.contributorCasabianca, Francoisen_US
dc.contributorCasu, Saraen_US
dc.contributorCiampolini, Robertaen_US
dc.contributorD’Acier, Armelleen_US
dc.contributorCoquelle, Corinneen_US
dc.contributorDelgado, Juan‐Vicenteen_US
dc.contributorElbeltagy, Ahmed R.en_US
dc.contributorHadjipavlou, Georgiaen_US
dc.contributorJousselin, Emmanuelleen_US
dc.contributorLandi, Vincenzoen_US
dc.contributorLauvie, Anneen_US
dc.contributorLecomte, Philippeen_US
dc.contributorLigda, Christinaen_US
dc.contributorMarinthe, Carolineen_US
dc.contributorMartinez, Amparoen_US
dc.contributorMastrangelo, Salvatoreen_US
dc.contributorMenni, Dalalen_US
dc.contributorMoulin, Charles-Henrien_US
dc.contributorOsman, Mona Abd El-Zaheren_US
dc.contributorPineau, Olivieren_US
dc.contributorPortolano, Baldassareen_US
dc.contributorRodellar, Clementinaen_US
dc.contributorSaidi‐Mehtar, Nadhiraen_US
dc.contributorSechi, Tizianaen_US
dc.contributorSempere, Guilhemen_US
dc.contributorThevenon, Sophieen_US
dc.contributorTsiokos, Dimitriosen_US
dc.contributorLaloe, Denisen_US
dc.contributorGautier, Mathieuen_US
dc.creatorFlori, Laurenceen_US
dc.identifier.citationLaurence Flori, Katayoun Moazami‐Goudarzi, Veronique Alary, Abdelillah Araba, Ismail Boujenane, Nadjet Boushaba, Francois Casabianca, Sara Casu, Roberta Ciampolini, Armelle D’Acier, Corinne Coquelle, Juan‐Vicente Delgado, Ahmed R. Elbeltagy, Georgia Hadjipavlou, Emmanuelle Jousselin, Vincenzo Landi, Anne Lauvie, Philippe Lecomte, Christina Ligda, Caroline Marinthe, Amparo Martinez, Salvatore Mastrangelo, Dalal Menni, Charles-Henri Moulin, Mona Abd El-Zaher Osman, Olivier Pineau, Baldassare Portolano, Clementina Rodellar, Nadhira Saidi‐Mehtar, Tiziana Sechi, Guilhem Sempere, Sophie Thevenon, Dimitrios Tsiokos, Denis Laloe, Mathieu Gautier. (1/3/2019). A genomic map of climate adaptation in Mediterranean cattle breeds. Molecular Ecology, 28 (5), pp. 1009-1029.en_US
dc.description.abstractDomestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attrac‐ tive biological models to characterize the genetic basis of short‐term evolutionary response to climate pressure induced by their post‐domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome‐wide association analyses with covariables discriminating the dif‐ ferent Mediterranean climate subtypes. This provided insights into both the demo‐ graphic and adaptive histories of Mediterranean cattle. In particular, a detailed functional annotation of genes surrounding variants associated with climate varia‐ tions highlighted several biological functions involved in Mediterranean climate adap‐ tation such as thermotolerance, UV protection, pathogen resistance or metabolism with strong candidate genes identified (e.g., NDUFB3, FBN1, METTL3, LEF1, ANTXR2 and TCF7). Accordingly, our results suggest that main selective pressures affecting cattle in Mediterranean area may have been related to variation in heat and UV expo‐ sure, in food resources availability and in exposure to pathogens, such as anthrax bacteria (Bacillus anthracis). Furthermore, the observed contribution of the three main bovine ancestries (indicine, European and African taurine) in these different popula‐ tions suggested that adaptation to local climate conditions may have either relied on standing genomic variation of taurine origin, or adaptive introgression from indicine origin, depending on the local breed origins. Taken together, our results highlight the genetic uniqueness of local Mediterranean cattle breeds and strongly support con‐ servation of these populations.en_US
dc.publisherWiley (12 months)en_US
dc.sourceMolecular Ecology;28,(2018) Pagination 1009,1029en_US
dc.subjectlocal adaptationen_US
dc.titleA genomic map of climate adaptation in Mediterranean cattle breedsen_US
dc.typeJournal Articleen_US
cg.creator.idAlary, Veronique: 0000-0003-4844-5423en_US
cg.contributor.centerThe French Agricultural Research Center for International Development - CIRADen_US
cg.contributor.centerFrench National Research Institute for Agriculture, Food and Environment, Animal Genetics, Joint research Unit for Animal Genetics and Interactive Biology - INRAE - AG - UMR GABIen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerInstitute of Agronomy and Veterinary Hassan II - IAV HASSAN IIen_US
cg.contributor.centerOran University of Science and Technology - Mohamed Boudiaf - USTOen_US
cg.contributor.centerFrench National Research Institute for Agriculture, Food and Environment - INRAE Franceen_US
cg.contributor.centerAgenzia per la ricerca in agricoltura , Servizio Ricerca per la Zootecnica - Agris-Sardegnaen_US
cg.contributor.centerUniversity of Pisa - UNIPIen_US
cg.contributor.centerFrench National Research Institute for Agriculture, Food and Environment, Plant Health and Environment, Joint research Unit: Center for Biology and Population Management - INRAE - SPA - UMR CBGPen_US
cg.contributor.centerIndependent / Not associateden_US
cg.contributor.centerUniversidad de Cordoba - UdCen_US
cg.contributor.centerAgricultural Research Center Egypt - ARC Egypten_US
cg.contributor.centerAgricultural Research Institute Cyprus - ARI Cyprusen_US
cg.contributor.centerUniversity of Montpellier - UMONTen_US
cg.contributor.centerThe Spanish National Research Centre, The Institute of Sustainable Agriculture - CSIC - IASen_US
cg.contributor.centerHellenic Agricultural Organization “Demeter” , Veterinary Research Institute - HAO-Demeter - VRIen_US
cg.contributor.centerAnimal Breeding Consultig sl. - ABC Consultingen_US
cg.contributor.centerUniversity of Palermo - unipaen_US
cg.contributor.centerAgricultural Research Center, Animal Production Research Institute - ARC - APRIen_US
cg.contributor.centerTour du Valaten_US
cg.contributor.centerUniversity of Zaragozaen_US
cg.contributor.centerUniversity of Montpellier, Computational Biology Institute - Montpellier - IBCen_US
cg.contributor.funderInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.projectCommunication and Documentation Information Services (CODIS)en_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
dc.identifier.statusTimeless limited accessen_US

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