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dc.contributorYang, Minen_US
dc.contributorLi, Yefangen_US
dc.contributorRouzi, Marhabaen_US
dc.contributorZhao, Qianjunen_US
dc.contributorPu, Yabinen_US
dc.contributorHe, Xiaohongen_US
dc.contributorMwacharo, Joramen_US
dc.contributorYang, Ningen_US
dc.contributorMa, Yuehuien_US
dc.contributorJiang, Linen_US
dc.creatorSong, Shenen_US
dc.date.accessioned2019-01-21T19:02:32Z
dc.date.available2019-01-21T19:02:32Z
dc.identifierhttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4864-xen_US
dc.identifierhttps://mel.cgiar.org/reporting/download/hash/4541173c3d8e1063578bdfd40740c7e8en_US
dc.identifier.citationShen Song, Min Yang, Yefang Li, Marhaba Rouzi, Qianjun Zhao, Yabin Pu, Xiaohong He, Joram Mwacharo, Ning Yang, Yuehui Ma, Lin Jiang. (26/12/2018). Genome-wide discovery of lincRNAs with spatiotemporal expression patterns in the skin of goat during the cashmere growth cycle. BMC Genomics, 19: 495.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/9252
dc.description.abstractBackground: Long intergenic noncoding RNAs (lincRNAs) have been recognized in recent years as key regulators of biological processes. However, lincRNAs in goat remain poorly characterized both across various tissues and during different developmental stages in goat (Capra hircus). Results: We performed the genome-wide discovery of the lincRNAs in goat by combining the RNA-seq dataset that were generated from 28 cashmere goat skin samples and the 12 datasets of goat tissues downloaded from the NCBI database. We identified a total of 5546 potential lincRNA transcripts that overlapped 3641 lincRNA genes. These lincRNAs exhibited a tissue-specific pattern. Specifically, there are 584 lincRNAs expressed exclusively in only one tissue, and 91 were highly expressed in hair follicle (HF). In addition, 2350 protein-coding genes and 492 lincRNAs were differentially expressed in the skin of goat. The majority exhibited the remarkable differential expression during the transition of the goat skin from the May–June to August–October time point, which covered the different seasons. Fundamental biological processes, such as skin development, were significantly enriched in these genes. Furthermore, we identified several lincRNAs highly expressed in the HF, which exhibited not only the co-expression pattern with the key factors to the HF development but also the activated expression in the August to October time point. Intriguingly, one of spatiotemporal lincRNAs, linc-chig1598 could be a potential regulator of distal-less homeobox 3 expression during the secondary hair follicle growth. Conclusions: This study will facilitate future studies aimed at unravelling the function of lincRNAs in hair follicle development.en_US
dc.formatPDFen_US
dc.languageenen_US
dc.publisherBioMed Centralen_US
dc.rightsCC-BY-4.0en_US
dc.sourceBMC Genomics;19:495,(2018)en_US
dc.subjectgoat skinen_US
dc.subjectlincrnaen_US
dc.subjecthair follicleen_US
dc.subjectcashmere growth cycleen_US
dc.titleGenome-wide discovery of lincRNAs with spatiotemporal expression patterns in the skin of goat during the cashmere growth cycleen_US
dc.typeJournal Articleen_US
dcterms.available2018-12-26en_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.subject.agrovoctranscriptomeen_US
cg.subject.agrovocGoatsen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerChina Agricultural University - CAU Chinaen_US
cg.contributor.centerChinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IASen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionEastern Asiaen_US
cg.coverage.countryCNen_US
cg.contactjianglin@caas.cnen_US
cg.identifier.doihttps://dx.doi.org/10.1186/s12864-018-4864-xen_US
cg.isijournalISI Journalen_US
dc.identifier.statusOpen accessen_US
mel.project.openhttps://mel.cgiar.org/projects/237en_US
mel.impact-factor3.730en_US
cg.issn1471-2164en_US
cg.journalBMC Genomicsen_US
cg.volume19:495en_US


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