dc.contributor | Yang, Ji | en_US |
dc.contributor | Xie, Xing-Long | en_US |
dc.contributor | Xu, Ya-Xi | en_US |
dc.contributor | Lv, Feng-Hua | en_US |
dc.contributor | Shen, Min | en_US |
dc.contributor | Yang, Hua | en_US |
dc.contributor | Yang, Yong-Lin | en_US |
dc.contributor | Liu, Chang-Bin | en_US |
dc.contributor | Zhou, Ping | en_US |
dc.contributor | Wan, Peng-Cheng | en_US |
dc.contributor | Zhang, Yun-Sheng | en_US |
dc.contributor | Gao, Lei | en_US |
dc.contributor | Yang, Jing-Quan | en_US |
dc.contributor | Pi, Wen-Hui | en_US |
dc.contributor | Ren, Yan-Ling | en_US |
dc.contributor | Shen, Zhi-Qiang | en_US |
dc.contributor | Wang, Feng | en_US |
dc.contributor | Deng, Juan | en_US |
dc.contributor | Xu, Song-Song | en_US |
dc.contributor | Salehian-Dehkordi, Hosein | en_US |
dc.contributor | Hehua, Eer | en_US |
dc.contributor | Esmailizadeh, Ali | en_US |
dc.contributor | Dehghani-Qanatqestani, Mostafa | en_US |
dc.contributor | Štěpánek, Ondřej | en_US |
dc.contributor | Weimann, Christina | en_US |
dc.contributor | Erhardt, Georg | en_US |
dc.contributor | Amane, Agraw | en_US |
dc.contributor | Mwacharo, Joram | en_US |
dc.contributor | Jianlin, Han | en_US |
dc.contributor | Hanotte, Olivier | en_US |
dc.contributor | A Lenstra, Johannes | en_US |
dc.contributor | Kantanen, Juha | en_US |
dc.contributor | Coltman, David W. | en_US |
dc.contributor | Kijas, James W. | en_US |
dc.contributor | W Bruford, Michael | en_US |
dc.contributor | Periasamy, Kathiravan | en_US |
dc.contributor | Wang, Xin-Hua | en_US |
dc.contributor | Li, Meng-Hua | en_US |
dc.creator | Li, Xin | en_US |
dc.date | 2020-06-04 | en_US |
dc.date.accessioned | 2020-10-08T16:53:13Z | |
dc.date.available | 2020-10-08T16:53:13Z | |
dc.identifier | https://mel.cgiar.org/reporting/download/hash/97abd98a3f6094de85dd8fab4bc31d85 | en_US |
dc.identifier.citation | Xin Li, Ji Yang, Xing-Long Xie, Ya-Xi Xu, Feng-Hua Lv, Min Shen, Hua Yang, Yong-Lin Yang, Chang-Bin Liu, Ping Zhou, Peng-Cheng Wan, Yun-Sheng Zhang, Lei Gao, Jing-Quan Yang, Wen-Hui Pi, Yan-Ling Ren, Zhi-Qiang Shen, Feng Wang, Juan Deng, Song-Song Xu, Hosein Salehian-Dehkordi, Eer Hehua, Ali Esmailizadeh, Mostafa Dehghani-Qanatqestani, Ondřej Štěpánek, Christina Weimann, Georg Erhardt, Agraw Amane, Joram Mwacharo, Han Jianlin, Olivier Hanotte, Johannes A Lenstra, Juha Kantanen, David W. Coltman, James W. Kijas, Michael W Bruford, Kathiravan Periasamy, Xin-Hua Wang, Meng-Hua Li. (4/6/2020). Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits. Nature Communications, 11, pp. 1-16. | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.11766/11883 | |
dc.description.abstract | Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals. | en_US |
dc.format | PDF | en_US |
dc.language | en | en_US |
dc.publisher | Nature Research (part of Springer Nature) (Fully open access journals) | en_US |
dc.rights | CC-BY-4.0 | en_US |
dc.source | Nature Communications;11,(2020) Pagination 1,16 | en_US |
dc.title | Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits | en_US |
dc.type | Journal Article | en_US |
cg.creator.id | Mwacharo, Joram: 0000-0001-6981-8140 | en_US |
cg.creator.id | Hanotte, Olivier: 0000-0002-2877-4767 | en_US |
cg.creator.ID-type | ORCID | en_US |
cg.creator.ID-type | ORCID | en_US |
cg.subject.agrovoc | livestock | en_US |
cg.subject.agrovoc | agronomic traits | en_US |
cg.contributor.center | Chinese Academy of Agricultural Sciences - CAAS | en_US |
cg.contributor.center | Chinese Academy of Sciences - CAS | en_US |
cg.contributor.center | Xinjiang Academy of Agricultural and Reclamation Sciences | en_US |
cg.contributor.center | Shandong Binzhou Academy of Animal Science and Veterinary Medicine | en_US |
cg.contributor.center | Nanjing Agricultural University | en_US |
cg.contributor.center | Ningxia Academy of Agriculture and Forestry Sciences | en_US |
cg.contributor.center | University of Kerman | en_US |
cg.contributor.center | State Veterinary Institute Jihlava | en_US |
cg.contributor.center | Justus Liebig University Giessen - JLU | en_US |
cg.contributor.center | Addis Ababa University - AAU | en_US |
cg.contributor.center | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.contributor.center | International Livestock Research Institute - ILRI | en_US |
cg.contributor.center | University of Nottingham, School of Life Sciences - UoN UK - School of Life Sciences | en_US |
cg.contributor.center | Utrecht University - UU | en_US |
cg.contributor.center | Luke Natural Resources Institute Finland - LUKE | en_US |
cg.contributor.center | University of Alberta | en_US |
cg.contributor.center | Commonwealth Science and Industrial Research Organisation - CSIRO | en_US |
cg.contributor.center | Cardiff University | en_US |
cg.contributor.center | International Atomic Energy Agency - IAEA | en_US |
cg.contributor.crp | CGIAR Research Program on Livestock Agri-Food Systems - LAFS | en_US |
cg.contributor.funder | International Livestock Research Institute - ILRI | en_US |
cg.contributor.project | CGIAR Research Program on Livestock Agri-Food Systems | en_US |
cg.contributor.project-lead-institute | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.coverage.region | Global | en_US |
cg.contact | 909064993@qq.com | en_US |
cg.identifier.doi | https://dx.doi.org/10.1038/s41467-020-16485-1 | en_US |
dc.identifier.status | Open access | en_US |
mel.project.open | https://mel.cgiar.org/projects/237 | en_US |
mel.impact-factor | 12.121 | en_US |