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dc.contributorYang, Jien_US
dc.contributorXie, Xing-Longen_US
dc.contributorXu, Ya-Xien_US
dc.contributorLv, Feng-Huaen_US
dc.contributorShen, Minen_US
dc.contributorYang, Huaen_US
dc.contributorYang, Yong-Linen_US
dc.contributorLiu, Chang-Binen_US
dc.contributorZhou, Pingen_US
dc.contributorWan, Peng-Chengen_US
dc.contributorZhang, Yun-Shengen_US
dc.contributorGao, Leien_US
dc.contributorYang, Jing-Quanen_US
dc.contributorPi, Wen-Huien_US
dc.contributorRen, Yan-Lingen_US
dc.contributorShen, Zhi-Qiangen_US
dc.contributorWang, Fengen_US
dc.contributorDeng, Juanen_US
dc.contributorXu, Song-Songen_US
dc.contributorSalehian-Dehkordi, Hoseinen_US
dc.contributorHehua, Eeren_US
dc.contributorEsmailizadeh, Alien_US
dc.contributorDehghani-Qanatqestani, Mostafaen_US
dc.contributorŠtěpánek, Ondřejen_US
dc.contributorWeimann, Christinaen_US
dc.contributorErhardt, Georgen_US
dc.contributorAmane, Agrawen_US
dc.contributorMwacharo, Joramen_US
dc.contributorJianlin, Hanen_US
dc.contributorHanotte, Olivieren_US
dc.contributorA Lenstra, Johannesen_US
dc.contributorKantanen, Juhaen_US
dc.contributorColtman, David W.en_US
dc.contributorKijas, James W.en_US
dc.contributorW Bruford, Michaelen_US
dc.contributorPeriasamy, Kathiravanen_US
dc.contributorWang, Xin-Huaen_US
dc.contributorLi, Meng-Huaen_US
dc.creatorLi, Xinen_US
dc.identifier.citationXin Li, Ji Yang, Xing-Long Xie, Ya-Xi Xu, Feng-Hua Lv, Min Shen, Hua Yang, Yong-Lin Yang, Chang-Bin Liu, Ping Zhou, Peng-Cheng Wan, Yun-Sheng Zhang, Lei Gao, Jing-Quan Yang, Wen-Hui Pi, Yan-Ling Ren, Zhi-Qiang Shen, Feng Wang, Juan Deng, Song-Song Xu, Hosein Salehian-Dehkordi, Eer Hehua, Ali Esmailizadeh, Mostafa Dehghani-Qanatqestani, Ondřej Štěpánek, Christina Weimann, Georg Erhardt, Agraw Amane, Joram Mwacharo, Han Jianlin, Olivier Hanotte, Johannes A Lenstra, Juha Kantanen, David W. Coltman, James W. Kijas, Michael W Bruford, Kathiravan Periasamy, Xin-Hua Wang, Meng-Hua Li. (4/6/2020). Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits. Nature Communications, 11, pp. 1-16.en_US
dc.description.abstractUnderstanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals.en_US
dc.publisherNature Research (part of Springer Nature) (Fully open access journals)en_US
dc.sourceNature Communications;11,(2020) Pagination 1,16en_US
dc.titleWhole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traitsen_US
dc.typeJournal Articleen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.creator.idHanotte, Olivier: 0000-0002-2877-4767en_US
cg.subject.agrovocagronomic traitsen_US
cg.contributor.centerChinese Academy of Agricultural Sciences - CAASen_US
cg.contributor.centerChinese Academy of Sciences - CASen_US
cg.contributor.centerXinjiang Academy of Agricultural and Reclamation Sciencesen_US
cg.contributor.centerShandong Binzhou Academy of Animal Science and Veterinary Medicineen_US
cg.contributor.centerNanjing Agricultural Universityen_US
cg.contributor.centerNingxia Academy of Agriculture and Forestry Sciencesen_US
cg.contributor.centerUniversity of Kermanen_US
cg.contributor.centerState Veterinary Institute Jihlavaen_US
cg.contributor.centerJustus Liebig University Giessen - JLUen_US
cg.contributor.centerAddis Ababa University - AAUen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerInternational Livestock Research Institute - ILRIen_US
cg.contributor.centerUniversity of Nottingham, School of Life Sciences - UoN UK - School of Life Sciencesen_US
cg.contributor.centerUtrecht University - UUen_US
cg.contributor.centerLuke Natural Resources Institute Finland - LUKEen_US
cg.contributor.centerUniversity of Albertaen_US
cg.contributor.centerCommonwealth Science and Industrial Research Organisation - CSIROen_US
cg.contributor.centerCardiff Universityen_US
cg.contributor.centerInternational Atomic Energy Agency - IAEAen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
dc.identifier.statusOpen accessen_US

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