Show simple item record

dc.contributorKhayatzadeh, Negaren_US
dc.contributorMelesse, Aberraen_US
dc.contributorWragg, Daviden_US
dc.contributorRekik, Mouraden_US
dc.contributorHaile, Aynalemen_US
dc.contributorRischkowsky, Barbaraen_US
dc.contributorRothschild, Max F.en_US
dc.contributorMwacharo, Joramen_US
dc.creatorDolebo, Asraten_US
dc.identifier.citationAsrat Dolebo, Negar Khayatzadeh, Aberra Melesse, David Wragg, Mourad Rekik, Aynalem Haile, Barbara Rischkowsky, Max F. Rothschild, Joram Mwacharo. (1/12/2019). Genome‑wide scans identify known and novel regions associated with prolifcacy and reproduction traits in a sub‑Saharan African indigenous sheep (Ovis aries). Mammalian Genome, 30, pp. 339-352.en_US
dc.description.abstractMaximizing the number of ofspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of ofspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains poorly understood in sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from the prolifc Bonga sheep in Ethiopia, 41 candidate regions under selection were identifed. The analysis revealed one strong selection signature on a candidate region on chromosome X spanning BMP15, suggesting this to be the primary candidate prolifcacy gene in the breed. The analysis also identifed several candidate regions spanning genes not reported before in prolifc sheep but underlying fertility and reproduction in other species. The genes associated with female reproduction traits included SPOCK1 (age at frst oestrus), GPR173 (mediator of ovarian cyclicity), HB-EGF (signalling early pregnancy success) and SMARCAL1 and HMGN3a (regulate gene expression during embryogenesis). The genes involved in male reproduction were FOXJ1 (sperm function and successful fertilization) and NME5 (spermatogenesis). We also observed genes such as PKD2L2, MAGED1 and KDM3B, which have been associated with diverse fertility traits in both sexes of other species. The results confrm the complexity of the genetic mechanisms underlying reproduction while suggesting that prolifcacy in the Bonga sheep, and possibly African indigenous sheep is partly under the control of BMP15 while other genes that enhance male and female fertility are essential for reproductive ftness.en_US
dc.publisherSpringer (part of Springer Nature)en_US
dc.sourceMammalian Genome;30,(2019) Pagination 339-352en_US
dc.subjectbonga sheepen_US
dc.titleGenome‑wide scans identify known and novel regions associated with prolifcacy and reproduction traits in a sub‑Saharan African indigenous sheep (Ovis aries)en_US
dc.typeJournal Articleen_US
cg.creator.idRekik, Mourad: 0000-0001-7455-2017en_US
cg.creator.idHaile, Aynalem: 0000-0001-5914-0487en_US
cg.creator.idRischkowsky, Barbara: 0000-0002-0035-471Xen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerHawassa University - HU - Ethiopiaen_US
cg.contributor.centerUniversity of Natural Resources and LIfe Science - BOKUen_US
cg.contributor.centerIowa State University - IASTATEen_US
cg.contributor.centerUniversity of Edinburgh, College of Medicine & Veterinary Medicine, Royal (Dick) School of Veterinary Studies - ED - CMVM - VETen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionEastern Africaen_US
cg.isijournalISI Journalen_US
dc.identifier.statusOpen accessen_US
cg.journalMammalian Genomeen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

DSpace software copyright © 2002-2016  DuraSpace
MELSpace content providers and partners accept no liability to any consequence resulting from use of the content or data made available in this repository. Users of this content assume full responsibility for compliance with all relevant national or international regulations and legislation.
Theme by 
Atmire NV