Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats

cg.contactJ.Mwacharo@cgiar.orgen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerInternational Livestock Research Institute - ILRIen_US
cg.contributor.centerUniversity of Sydneyen_US
cg.contributor.centerAddis Ababa University - AAUen_US
cg.contributor.centerUniversity of Oxford - Oxforden_US
cg.contributor.centerTigray Agricultural Research Institute - TARIen_US
cg.contributor.centerChinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IASen_US
cg.contributor.centerUniversity of Nottingham, School of Life Sciences - UoN UK - School of Life Sciencesen_US
cg.contributor.centerScotland's Rural College - SRUCen_US
cg.contributor.centerMisurata Universityen_US
cg.contributor.centerCAAS‑ILRI Joint Laboratory On Livestock and Forage Genetic Resources, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences (CAAS)en_US
cg.contributor.centerJackson Laboratory - JAXen_US
cg.contributor.centerWashington University in St. Louis - WashUen_US
cg.contributor.centerUniversity of Liverpool - Liverpoolen_US
cg.contributor.crpResilient Agrifood Systems - RAFSen_US
cg.contributor.funderInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.funderCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderTigray Agricultural Research Institute - TARIen_US
cg.contributor.funderUnited Kingdom Research and Innovation - UKRIen_US
cg.contributor.funderBiotechnology and Biological Sciences Research Council - BBSRCen_US
cg.contributor.funderUniversity of Liverpool - Liverpoolen_US
cg.contributor.initiativeSustainable Animal Productivityen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.countryETen_US
cg.coverage.regionEastern Africaen_US
cg.creator.idDessie, Tadelle: 0000-0002-1630-0417en_US
cg.creator.idTarekegn, Getinet: 0000-0001-7221-2473en_US
cg.creator.idHanotte, Olivier: 0000-0002-2877-4767en_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.identifier.doihttps://dx.doi.org/10.1038/s41598-024-65303-xen_US
cg.isijournalISI Journalen_US
cg.issn2045-2322en_US
cg.journalScientific Reportsen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.agrovocgoatsen_US
cg.subject.agrovocethiopiaen_US
cg.subject.agrovocgeneticsen_US
cg.subject.agrovocanimal breedingen_US
cg.subject.agrovocgoatsen_US
cg.subject.impactAreaClimate adaptation and mitigationen_US
cg.subject.impactAreaEnvironmental health and biodiversityen_US
cg.subject.sdgSDG 1 - No povertyen_US
cg.subject.sdgSDG 13 - Climate actionen_US
cg.volume14en_US
dc.contributorBelay, Gurjaen_US
dc.contributorNigussie, Helenen_US
dc.contributorAhbara, Abulgasimen_US
dc.contributorTijjani, Abdulfataien_US
dc.contributorDessie, Tadelleen_US
dc.contributorTarekegn, Getineten_US
dc.contributorJianlin, Hanen_US
dc.contributorMor, Siobhanen_US
dc.contributorWoldekiros, Helina S.en_US
dc.contributorDobney, Keithen_US
dc.contributorLebrasseur, Ophelieen_US
dc.contributorHanotte, Olivieren_US
dc.contributorMwacharo, Joramen_US
dc.creatorBelay, Shumuyeen_US
dc.date.accessioned2024-09-05T19:12:45Z
dc.date.available2024-09-05T19:12:45Z
dc.description.abstractAnthropological and biophysical processes have shaped livestock genomes over Millenia and can explain their current geographic distribution and genetic divergence. We analyzed 57 Ethiopian indigenous domestic goat genomes alongside 67 equivalents of east, west, and north-west African, European, South Asian, Middle East, and wild Bezoar goats. Cluster, ADMIXTURE (K = 4) and phylogenetic analysis revealed four genetic groups comprising African, European, South Asian, and wild Bezoar goats. The Middle Eastern goats had an admixed genome of these four genetic groups. At K = 5, the West African Dwarf and Moroccan goats were separated from East African goats demonstrating a likely historical legacy of goat arrival and dispersal into Africa via the coastal Mediterranean Sea and the Horn of Africa. FST, XP-EHH, and Hp analysis revealed signatures of selection in Ethiopian goats overlaying genes for thermo-sensitivity, oxidative stress response, high-altitude hypoxic adaptation, reproductive fitness, pathogen defence, immunity, pigmentation, DNA repair, modulation of renal function and integrated fluid and electrolyte homeostasis. Notable examples include TRPV1 (a nociception gene); PTPMT1 (a critical hypoxia survival gene); RETREG (a regulator of reticulophagy during starvation), and WNK4 (a molecular switch for osmoregulation). These results suggest that human-mediated translocations and adaptation to contrasting environments are shaping indigenous African goat genomes.en_US
dc.formatPDFen_US
dc.identifierhttps://mel.cgiar.org/reporting/downloadmelspace/hash/9822a021466d461c0bd5cab2b08cbe95en_US
dc.identifier.citationShumuye Belay, Gurja Belay, Helen Nigussie, Abulgasim Ahbara, Abdulfatai Tijjani, Tadelle Dessie, Getinet Tarekegn, Han Jianlin, Siobhan Mor, Helina S. Woldekiros, Keith Dobney, Ophelie Lebrasseur, Olivier Hanotte, Joram Mwacharo. (28/6/2024). Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats. Scientific Reports, 14.en_US
dc.identifier.statusOpen accessen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/69500
dc.languageenen_US
dc.publisherNature Research (part of Springer Nature) (Fully open access journals)en_US
dc.rightsCC-BY-4.0en_US
dc.sourceScientific Reports;14,(2024)en_US
dc.subjectindigenous goatsen_US
dc.titleAnthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goatsen_US
dc.typeJournal Articleen_US
dcterms.available2024-06-28en_US
dcterms.issued2024-06-28en_US
mel.impact-factor3.8en_US

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