Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats
cg.contact | J.Mwacharo@cgiar.org | en_US |
cg.contributor.center | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.contributor.center | International Livestock Research Institute - ILRI | en_US |
cg.contributor.center | University of Sydney | en_US |
cg.contributor.center | Addis Ababa University - AAU | en_US |
cg.contributor.center | University of Oxford - Oxford | en_US |
cg.contributor.center | Tigray Agricultural Research Institute - TARI | en_US |
cg.contributor.center | Chinese Academy of Agricultural Sciences, Institute of Animal Science - CAAS - IAS | en_US |
cg.contributor.center | University of Nottingham, School of Life Sciences - UoN UK - School of Life Sciences | en_US |
cg.contributor.center | Scotland's Rural College - SRUC | en_US |
cg.contributor.center | Misurata University | en_US |
cg.contributor.center | CAAS‑ILRI Joint Laboratory On Livestock and Forage Genetic Resources, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences (CAAS) | en_US |
cg.contributor.center | Jackson Laboratory - JAX | en_US |
cg.contributor.center | Washington University in St. Louis - WashU | en_US |
cg.contributor.center | University of Liverpool - Liverpool | en_US |
cg.contributor.crp | Resilient Agrifood Systems - RAFS | en_US |
cg.contributor.funder | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.contributor.funder | International Livestock Research Institute - ILRI | en_US |
cg.contributor.funder | CGIAR Research Program on Livestock Agri-Food Systems - Livestock | en_US |
cg.contributor.funder | Tigray Agricultural Research Institute - TARI | en_US |
cg.contributor.funder | United Kingdom Research and Innovation - UKRI | en_US |
cg.contributor.funder | Biotechnology and Biological Sciences Research Council - BBSRC | en_US |
cg.contributor.funder | University of Liverpool - Liverpool | en_US |
cg.contributor.initiative | Sustainable Animal Productivity | en_US |
cg.contributor.project-lead-institute | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.coverage.country | ET | en_US |
cg.coverage.region | Eastern Africa | en_US |
cg.creator.id | Dessie, Tadelle: 0000-0002-1630-0417 | en_US |
cg.creator.id | Tarekegn, Getinet: 0000-0001-7221-2473 | en_US |
cg.creator.id | Hanotte, Olivier: 0000-0002-2877-4767 | en_US |
cg.creator.id | Mwacharo, Joram: 0000-0001-6981-8140 | en_US |
cg.identifier.doi | https://dx.doi.org/10.1038/s41598-024-65303-x | en_US |
cg.isijournal | ISI Journal | en_US |
cg.issn | 2045-2322 | en_US |
cg.journal | Scientific Reports | en_US |
cg.subject.actionArea | Resilient Agrifood Systems | en_US |
cg.subject.agrovoc | goats | en_US |
cg.subject.agrovoc | ethiopia | en_US |
cg.subject.agrovoc | genetics | en_US |
cg.subject.agrovoc | animal breeding | en_US |
cg.subject.agrovoc | goats | en_US |
cg.subject.impactArea | Climate adaptation and mitigation | en_US |
cg.subject.impactArea | Environmental health and biodiversity | en_US |
cg.subject.sdg | SDG 1 - No poverty | en_US |
cg.subject.sdg | SDG 13 - Climate action | en_US |
cg.volume | 14 | en_US |
dc.contributor | Belay, Gurja | en_US |
dc.contributor | Nigussie, Helen | en_US |
dc.contributor | Ahbara, Abulgasim | en_US |
dc.contributor | Tijjani, Abdulfatai | en_US |
dc.contributor | Dessie, Tadelle | en_US |
dc.contributor | Tarekegn, Getinet | en_US |
dc.contributor | Jianlin, Han | en_US |
dc.contributor | Mor, Siobhan | en_US |
dc.contributor | Woldekiros, Helina S. | en_US |
dc.contributor | Dobney, Keith | en_US |
dc.contributor | Lebrasseur, Ophelie | en_US |
dc.contributor | Hanotte, Olivier | en_US |
dc.contributor | Mwacharo, Joram | en_US |
dc.creator | Belay, Shumuye | en_US |
dc.date.accessioned | 2024-09-05T19:12:45Z | |
dc.date.available | 2024-09-05T19:12:45Z | |
dc.description.abstract | Anthropological and biophysical processes have shaped livestock genomes over Millenia and can explain their current geographic distribution and genetic divergence. We analyzed 57 Ethiopian indigenous domestic goat genomes alongside 67 equivalents of east, west, and north-west African, European, South Asian, Middle East, and wild Bezoar goats. Cluster, ADMIXTURE (K = 4) and phylogenetic analysis revealed four genetic groups comprising African, European, South Asian, and wild Bezoar goats. The Middle Eastern goats had an admixed genome of these four genetic groups. At K = 5, the West African Dwarf and Moroccan goats were separated from East African goats demonstrating a likely historical legacy of goat arrival and dispersal into Africa via the coastal Mediterranean Sea and the Horn of Africa. FST, XP-EHH, and Hp analysis revealed signatures of selection in Ethiopian goats overlaying genes for thermo-sensitivity, oxidative stress response, high-altitude hypoxic adaptation, reproductive fitness, pathogen defence, immunity, pigmentation, DNA repair, modulation of renal function and integrated fluid and electrolyte homeostasis. Notable examples include TRPV1 (a nociception gene); PTPMT1 (a critical hypoxia survival gene); RETREG (a regulator of reticulophagy during starvation), and WNK4 (a molecular switch for osmoregulation). These results suggest that human-mediated translocations and adaptation to contrasting environments are shaping indigenous African goat genomes. | en_US |
dc.format | en_US | |
dc.identifier | https://mel.cgiar.org/reporting/downloadmelspace/hash/9822a021466d461c0bd5cab2b08cbe95 | en_US |
dc.identifier.citation | Shumuye Belay, Gurja Belay, Helen Nigussie, Abulgasim Ahbara, Abdulfatai Tijjani, Tadelle Dessie, Getinet Tarekegn, Han Jianlin, Siobhan Mor, Helina S. Woldekiros, Keith Dobney, Ophelie Lebrasseur, Olivier Hanotte, Joram Mwacharo. (28/6/2024). Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats. Scientific Reports, 14. | en_US |
dc.identifier.status | Open access | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.11766/69500 | |
dc.language | en | en_US |
dc.publisher | Nature Research (part of Springer Nature) (Fully open access journals) | en_US |
dc.rights | CC-BY-4.0 | en_US |
dc.source | Scientific Reports;14,(2024) | en_US |
dc.subject | indigenous goats | en_US |
dc.title | Anthropogenic events and responses to environmental stress are shaping the genomes of Ethiopian indigenous goats | en_US |
dc.type | Journal Article | en_US |
dcterms.available | 2024-06-28 | en_US |
dcterms.issued | 2024-06-28 | en_US |
mel.impact-factor | 3.8 | en_US |
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