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dc.contributorHammoudeh, Sarahen_US
dc.contributorRadwan, Hadiaen_US
dc.contributorManzoor, Shaistaen_US
dc.contributorJabbar, Husseinen_US
dc.contributorWardeh, Rahafen_US
dc.contributorAshraf, Ahmeden_US
dc.contributorHabib, Peteren_US
dc.contributorM.Alsamman, Alsammanen_US
dc.contributorHamoudiab, Rifaten_US
dc.creatorSaber-Ayad, Mahaen_US
dc.date2020-07-01en_US
dc.date.accessioned2020-10-07T07:58:52Z
dc.date.available2020-10-07T07:58:52Z
dc.identifierhttps://mel.cgiar.org/reporting/download/hash/5838c37e347be5165476cc8137c67ad9en_US
dc.identifier.citationMaha Saber-Ayad, Sarah Hammoudeh, Hadia Radwan, Shaista Manzoor, Hussein Jabbar, Rahaf Wardeh, Ahmed Ashraf, Peter Habib, Alsamman M. Alsamman, Rifat Hamoudiab. (1/7/2020). The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population. Journal of Advanced Research, 24, pp. 485-494.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/11876
dc.description.abstractFood predilection is linked to variants in the hepatokine Fibroblast Growth Factor-21 gene (FGF21); with rs838133 linked to the sweet tooth in Caucasians. The effect of FGF21 variants on food intake is still unclear in other populations. A cohort of 196 healthy Emirati subjects was investigated [age: 30.34 +/- 9. 75yrs (44.4% males)]. The FGF21 rs838133 and rs838145 were genotyped. The daily intake was calculated based on a 61-item food frequency questionnaire. Multivariate analysis was performed using in house R script that implements two-way unsupervised hierarchical clustering to detect the association of the studied single-nucleotide polymorphisms (SNPs) and related SNPs in linkage disequilibrium, using data from the 1000 genome project. Both SNPs were in Hardy-Weinberg Equilaribium (HWE). BMI positively correlated with age (p = 0.002), but not with caloric intake. Salt intake was significantly higher in subjects homozygous (A: rs838133) and (G:rs838145),(p = 0.03 and 0.01, respectively). An interaction was observed between both SNPs; significantly associated with high salt intake. Using publicly available data, both SNPs fall within a region transmitted in Iberians which has a profile closely similar to Caucasians, but far from Chinese population. In conclusion, the minor alleles of FGF21 rs838145 and rs838133 are associated with high salt intake in Emiratis and may suggest neuro-metabolic link to dietary preference across different populations. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.formatPDFen_US
dc.languageenen_US
dc.publisherElsevieren_US
dc.rightsCC-BY-NC-ND-4.0en_US
dc.sourceJournal of Advanced Research;24,(2020) Pagination 485,494en_US
dc.subjectsalt intakeen_US
dc.subjectfgf21en_US
dc.subjectfood frequency questionnaire (ffq)en_US
dc.subjectmultiple correspondence analysisen_US
dc.titleThe FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati populationen_US
dc.typeJournal Articleen_US
cg.subject.agrovocunited arab emiratesen_US
cg.subject.agrovocfood intakeen_US
cg.contributor.centerUniversity of Sharjah, College of Medicineen_US
cg.contributor.centerUniversity of Sharjah, Research Institute for Medical and Health Sciencesen_US
cg.contributor.centerUniversity of Cairo, College of Medicine - CU - CoMen_US
cg.contributor.centerUniversity of Sharjah, College of Health Sciencesen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerAgricultural Genetic Engineering Research Institute - AGERIen_US
cg.contributor.funderInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.projectCommunication and Documentation Information Services (CODIS)en_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionGlobalen_US
cg.contactmsaber@sharjah.ac.aeen_US
cg.identifier.doihttps://dx.doi.org/10.1016/j.jare.2020.05.020en_US
dc.identifier.statusOpen accessen_US
mel.impact-factor6.992en_US


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