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dc.contributorMwacharo, Joramen_US
dc.contributorPelle, Rogeren_US
dc.contributorNjahira, Mosesen_US
dc.contributorOdongo, Daviden_US
dc.contributorMbole-Kariuki, Maryen_US
dc.contributorMarcellino, Wanien_US
dc.contributorMalak, Agolen_US
dc.contributorKiara, Henaryen_US
dc.contributorEl Hussein, Abdel Rahimen_US
dc.contributorBishop, Richard P.en_US
dc.contributorSkilton, Roberten_US
dc.creatorSalih, Diaeldinen_US
dc.identifier.citationDiaeldin Salih, Joram Mwacharo, Joram Mwacharo, Roger Pelle, Moses Njahira, Moses Njahira, David Odongo, David Odongo, Mary Mbole-Kariuki, Wani Marcellino, Agol Malak, Henary Kiara, Abdel Rahim El Hussein, Richard P. Bishop, Robert Skilton. (1/5/2018). Genetic diversity and population structure of Theileria parva in South Sudan. Ticks and Tick-borne Diseases, 9(4), pp. 806-813.en_US
dc.description.abstractTheileria parva is a parasitic protozoan that causes East Coast fever (ECF), an economically important disease of cattle in eastern, central and southern Africa. In South Sudan, ECF is considered a major constraint for livestock development in regions where the disease is endemic. To obtain insights into the dynamics of T. parva in South Sudan, population genetic analysis was performed. Out of the 751 samples included in this study, 178 blood samples were positive for T. parva by species-specific PCR, were collected from cattle from four regions in South Sudan (Bor = 62; Juba = 45; Kajo keji = 41 and Yei = 30) were genotyped using 14 microsatellite markers spanning the four chromosomes. The T. parva Muguga strain was included in the study as a reference. Linkage disequilibrium was evident when populations from the four regions were treated as a single entity, but, when populations were analyzed separately, linkage disequilibrium was observed in Bor, Juba and Kajo keji. Juba region had a higher multiplicity of infection than the other three regions. Principal components analysis revealed a degree of sub-structure between isolates from each region, suggesting that populations are partially distinct, with genetic exchange and gene flow being limited between parasites in the four geographically separated populations studied. Panmixia was observed within individual populations. Overall T. parva population genetic analyses of four populations in South Sudan exhibited a low level of genetic exchange between the populations, but a high level of genetic diversity within each population.en_US
dc.publisherElsevier (12 months)en_US
dc.sourceTicks and Tick-borne Diseases;9,(2018) Pagination 806,813en_US
dc.titleGenetic diversity and population structure of Theileria parva in South Sudanen_US
dc.typeJournal Articleen_US
cg.subject.agrovoctheileria parvaen_US
cg.subject.agrovocsouth sudanen_US
cg.contributor.centerBiosciences Eastern and Central Africa - BeCAen_US
cg.contributor.centerCentral Veterinary Research Laboratoryen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerUniversity of Nottingham - UoN UKen_US
cg.contributor.centerInternational Center of Insect Physiology and Ecology - ICIPEen_US
cg.contributor.centerInternational Livestock Research Institute - ILRIen_US
cg.contributor.centerUniversity of Nairobi, School of Biological Sciences - UONBI - SBSen_US
cg.contributor.centerMinistry of Animal Resources and Fisheriesen_US
cg.contributor.crpCRP on Livestock Agri-Food Systems - LAFSen_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.regionEastern Africaen_US
dc.identifier.statusTimeless limited accessen_US

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