Serial Translocation By Means Of Circular Intermediates Underlies Colour Sidedness In Cattle

cg.contactmichel.georges@ulg.ac.been_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerUniversity of Natural Resources and Life Sciences, Center for Development Research - BOKU - CDRen_US
cg.contributor.centerUniversity of Natural Resources and LIfe Science - BOKUen_US
cg.contributor.centerBern University of Applied Sciences, School of Agriculture, Forest and Food Sciencesen_US
cg.contributor.centerUniversity of Liège, Faculty of Veterinary Medicine - ULIEGE - FMVen_US
cg.contributor.centerUniversity of Bern, Institute of Geneticsen_US
cg.contributor.centerUniversity of Veterinary Sciences Brno, Institute of Genetics - VFUen_US
cg.contributor.centerKey Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of Chinaen_US
cg.contributor.centerFondation Jean Dausset – Centre d’Etude du Polymorphisme Humainen_US
cg.contributor.centerCentre for Genetic Resources the Netherlands (CGN)en_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderUniversity of Liège, Faculty of Veterinary Medicine - ULIEGE - FMVen_US
cg.contributor.funderWalloon Direction General Operationnelle Agriculture, Resources Naturelles et Environnementen_US
cg.contributor.funderSwiss National Science Foundationen_US
cg.contributor.projectCommunication and Documentation Information Services (CODIS)en_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.creator.idHaile, Aynalem: 0000-0001-5914-0487en_US
cg.date.embargo-end-dateTimelessen_US
cg.identifier.doihttps://dx.doi.org/10.1038/nature10757en_US
cg.isijournalISI Journalen_US
cg.issn0028-0836en_US
cg.issue7383en_US
cg.journalNatureen_US
cg.subject.agrovoccattleen_US
cg.subject.agrovoccolour sidednessen_US
cg.volume482en_US
dc.contributorCoppieters, Wouteren_US
dc.contributorDrögemüller, Corden_US
dc.contributorAhariz, Naimaen_US
dc.contributorCambisano, Nadineen_US
dc.contributorDruet, Tomen_US
dc.contributorFasquelle, Corinneen_US
dc.contributorHaile, Aynalemen_US
dc.contributorHorin, Petren_US
dc.contributorHuang, Lushengen_US
dc.contributorKamatani, Yohichiroen_US
dc.contributorKarim, Latifaen_US
dc.contributorLathrop, Marken_US
dc.contributorMoser, Simonen_US
dc.contributorOldenbroek, Koren_US
dc.contributorRieder, Stefanen_US
dc.contributorSartelet, Arnauden_US
dc.contributorSölkner, Johannen_US
dc.contributorStålhammar, Hansen_US
dc.contributorZelenika, Dianaen_US
dc.contributorZhang, Zhiyanen_US
dc.contributorLeeb, Tossoen_US
dc.contributorGeorges, Michelen_US
dc.contributorCharlier, Caroleen_US
dc.creatorDurkin, Keithen_US
dc.date.accessioned2021-05-07T20:28:49Z
dc.date.available2021-05-07T20:28:49Z
dc.description.abstractColour sidedness is a dominantly inherited phenotype of cattle characterized by the polarization of pigmented sectors on the flanks, snout and ear tips(1). It is also referred to as 'lineback' or 'witrik' (which means white back), as colour-sided animals typically display a white band along their spine. Colour sidedness is documented at least since the Middle Ages and is presently segregating in several cattle breeds around the globe, including in Belgian blue and brown Swiss(1,2). Here we report that colour sidedness is determined by a first allele on chromosome 29 (Cs-29), which results from the translocation of a 492-kilobase chromosome 6 segment encompassing KIT to chromosome 29, and a second allele on chromosome 6 (Cs-6), derived from the first by repatriation of fused 575-kilobase chromosome 6 and 29 sequences to the KIT locus. We provide evidence that both translocation events involved circular intermediates. This is the first example, to our knowledge, of a phenotype determined by homologous yet non-syntenic alleles that result from a novel copy-number-variant-generating mechanism.en_US
dc.formatPDFen_US
dc.identifierhttps://mel.cgiar.org/dspace/limiteden_US
dc.identifier.citationKeith Durkin, Wouter Coppieters, Cord Drögemüller, Naima Ahariz, Nadine Cambisano, Tom Druet, Corinne Fasquelle, Aynalem Haile, Petr Horin, Lusheng Huang, Yohichiro Kamatani, Latifa Karim, Mark Lathrop, Simon Moser, Kor Oldenbroek, Stefan Rieder, Arnaud Sartelet, Johann Sölkner, Hans Stålhammar, Diana Zelenika, Zhiyan Zhang, Tosso Leeb, Michel Georges, Carole Charlier. (1/2/2012). Serial Translocation By Means Of Circular Intermediates Underlies Colour Sidedness In Cattle. Nature, 482 (7383), pp. 81-84.en_US
dc.identifier.statusTimeless limited accessen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/13087
dc.languageenen_US
dc.publisherNature Publishing Groupen_US
dc.sourceNature;482,Pagination 81-84en_US
dc.subjectserial translocationen_US
dc.subjectcircular intermediatesen_US
dc.titleSerial Translocation By Means Of Circular Intermediates Underlies Colour Sidedness In Cattleen_US
dc.typeJournal Articleen_US
dcterms.available2012-02-01en_US
dcterms.extent81-84en_US
dcterms.issued2012-02-01en_US
mel.impact-factor42.778en_US

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