Serial Translocation By Means Of Circular Intermediates Underlies Colour Sidedness In Cattle
cg.contact | michel.georges@ulg.ac.be | en_US |
cg.contributor.center | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.contributor.center | University of Natural Resources and Life Sciences, Center for Development Research - BOKU - CDR | en_US |
cg.contributor.center | University of Natural Resources and LIfe Science - BOKU | en_US |
cg.contributor.center | Bern University of Applied Sciences, School of Agriculture, Forest and Food Sciences | en_US |
cg.contributor.center | University of Liège, Faculty of Veterinary Medicine - ULIEGE - FMV | en_US |
cg.contributor.center | University of Bern, Institute of Genetics | en_US |
cg.contributor.center | University of Veterinary Sciences Brno, Institute of Genetics - VFU | en_US |
cg.contributor.center | Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China | en_US |
cg.contributor.center | Fondation Jean Dausset – Centre d’Etude du Polymorphisme Humain | en_US |
cg.contributor.center | Centre for Genetic Resources the Netherlands (CGN) | en_US |
cg.contributor.crp | CGIAR Research Program on Livestock Agri-Food Systems - Livestock | en_US |
cg.contributor.funder | University of Liège, Faculty of Veterinary Medicine - ULIEGE - FMV | en_US |
cg.contributor.funder | Walloon Direction General Operationnelle Agriculture, Resources Naturelles et Environnement | en_US |
cg.contributor.funder | Swiss National Science Foundation | en_US |
cg.contributor.project | Communication and Documentation Information Services (CODIS) | en_US |
cg.contributor.project-lead-institute | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.creator.id | Haile, Aynalem: 0000-0001-5914-0487 | en_US |
cg.date.embargo-end-date | Timeless | en_US |
cg.identifier.doi | https://dx.doi.org/10.1038/nature10757 | en_US |
cg.isijournal | ISI Journal | en_US |
cg.issn | 0028-0836 | en_US |
cg.issue | 7383 | en_US |
cg.journal | Nature | en_US |
cg.subject.agrovoc | cattle | en_US |
cg.subject.agrovoc | colour sidedness | en_US |
cg.volume | 482 | en_US |
dc.contributor | Coppieters, Wouter | en_US |
dc.contributor | Drögemüller, Cord | en_US |
dc.contributor | Ahariz, Naima | en_US |
dc.contributor | Cambisano, Nadine | en_US |
dc.contributor | Druet, Tom | en_US |
dc.contributor | Fasquelle, Corinne | en_US |
dc.contributor | Haile, Aynalem | en_US |
dc.contributor | Horin, Petr | en_US |
dc.contributor | Huang, Lusheng | en_US |
dc.contributor | Kamatani, Yohichiro | en_US |
dc.contributor | Karim, Latifa | en_US |
dc.contributor | Lathrop, Mark | en_US |
dc.contributor | Moser, Simon | en_US |
dc.contributor | Oldenbroek, Kor | en_US |
dc.contributor | Rieder, Stefan | en_US |
dc.contributor | Sartelet, Arnaud | en_US |
dc.contributor | Sölkner, Johann | en_US |
dc.contributor | Stålhammar, Hans | en_US |
dc.contributor | Zelenika, Diana | en_US |
dc.contributor | Zhang, Zhiyan | en_US |
dc.contributor | Leeb, Tosso | en_US |
dc.contributor | Georges, Michel | en_US |
dc.contributor | Charlier, Carole | en_US |
dc.creator | Durkin, Keith | en_US |
dc.date.accessioned | 2021-05-07T20:28:49Z | |
dc.date.available | 2021-05-07T20:28:49Z | |
dc.description.abstract | Colour sidedness is a dominantly inherited phenotype of cattle characterized by the polarization of pigmented sectors on the flanks, snout and ear tips(1). It is also referred to as 'lineback' or 'witrik' (which means white back), as colour-sided animals typically display a white band along their spine. Colour sidedness is documented at least since the Middle Ages and is presently segregating in several cattle breeds around the globe, including in Belgian blue and brown Swiss(1,2). Here we report that colour sidedness is determined by a first allele on chromosome 29 (Cs-29), which results from the translocation of a 492-kilobase chromosome 6 segment encompassing KIT to chromosome 29, and a second allele on chromosome 6 (Cs-6), derived from the first by repatriation of fused 575-kilobase chromosome 6 and 29 sequences to the KIT locus. We provide evidence that both translocation events involved circular intermediates. This is the first example, to our knowledge, of a phenotype determined by homologous yet non-syntenic alleles that result from a novel copy-number-variant-generating mechanism. | en_US |
dc.format | en_US | |
dc.identifier | https://mel.cgiar.org/dspace/limited | en_US |
dc.identifier.citation | Keith Durkin, Wouter Coppieters, Cord Drögemüller, Naima Ahariz, Nadine Cambisano, Tom Druet, Corinne Fasquelle, Aynalem Haile, Petr Horin, Lusheng Huang, Yohichiro Kamatani, Latifa Karim, Mark Lathrop, Simon Moser, Kor Oldenbroek, Stefan Rieder, Arnaud Sartelet, Johann Sölkner, Hans Stålhammar, Diana Zelenika, Zhiyan Zhang, Tosso Leeb, Michel Georges, Carole Charlier. (1/2/2012). Serial Translocation By Means Of Circular Intermediates Underlies Colour Sidedness In Cattle. Nature, 482 (7383), pp. 81-84. | en_US |
dc.identifier.status | Timeless limited access | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.11766/13087 | |
dc.language | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.source | Nature;482,Pagination 81-84 | en_US |
dc.subject | serial translocation | en_US |
dc.subject | circular intermediates | en_US |
dc.title | Serial Translocation By Means Of Circular Intermediates Underlies Colour Sidedness In Cattle | en_US |
dc.type | Journal Article | en_US |
dcterms.available | 2012-02-01 | en_US |
dcterms.extent | 81-84 | en_US |
dcterms.issued | 2012-02-01 | en_US |
mel.impact-factor | 42.778 | en_US |