Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine

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cg.contacthatem.zayed@qu.edu.qaen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerAgricultural Genetic Engineering Research Institute - AGERIen_US
cg.contributor.centerQatar universityen_US
cg.contributor.centerUniversity of Bonn, Institute for Genomics Statistics and Bioinformaticsen_US
cg.contributor.centerUniversity of Bonn, Institute for Human Geneticsen_US
cg.contributor.centerUniversity of Marburg, Centre for Human Geneticsen_US
cg.contributor.funderInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.projectCommunication and Documentation Information Services (CODIS)en_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.countryQAen_US
cg.coverage.regionWestern Asiaen_US
cg.identifier.doihttps://doi.org/10.1186/s12014-024-09519-zen_US
cg.isijournalISI Journalen_US
cg.issn1542-6416en_US
cg.journalClinical Proteomicsen_US
cg.subject.agrovoccardiovascular diseasesen_US
cg.subject.agrovochypertensionen_US
cg.volume22en_US
dc.contributorAlsamman, Alsamman M.en_US
dc.contributorKrawitz, Peteren_US
dc.contributorMaj, Carloen_US
dc.contributorZayed, Hatemen_US
dc.creatorAldisi, Rana S.en_US
dc.date.accessioned2025-08-01T18:40:48Z
dc.date.available2025-08-01T18:40:48Z
dc.description.abstractBackground Hypertension is a critical public health issue worldwide. The identification of specific proteomic biomarkers in the Qatari population aims to advance personalized treatment strategies. Methods We conducted proteomic profiling on 778 Qatari individuals using an aptamer-based SOMAscan platform to analyze 1,305 biomarkers. Statistical analysis involved two-way ANOVA and association analyses with FDR correction, alongside pathway and gene-set enrichment analyses using Reactome and DisGeNET databases. Results The study identified 26 significant protein biomarkers associated with hypertension. Notably, QORL1 and BMP1 were identified as novel protein biomarkers. Enrichment analysis linked these biomarkers to critical pathways involved in vascular biology, immune system responses, and pathologies like arteriosclerosis and coronary artery disease. Correlation analyses highlighted robust interactions, particularly between QORL1 and various Apolipoprotein E isoforms, suggesting these biomarkers play pivotal roles in the molecular mechanisms underlying hypertension.en_US
dc.formatPDFen_US
dc.identifierhttps://mel.cgiar.org/reporting/downloadmelspace/hash/5118079b5db4b545d4b0188c6f0aa955en_US
dc.identifier.citationRana S. Aldisi, Alsamman M. Alsamman, Peter Krawitz, Carlo Maj, Hatem Zayed. (12/2/2025). Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine. Clinical Proteomics, 22.en_US
dc.identifier.statusOpen accessen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/70034
dc.languageenen_US
dc.publisherBioMed Centralen_US
dc.rightsCC-BY-NC-ND-4.0en_US
dc.sourceClinical Proteomics;22,(2025)en_US
dc.subjectqatar precision health institute-qatar biobanken_US
dc.subjectproteomic/macromolecular biomarkersen_US
dc.subjectqorl1en_US
dc.subjectbmp1en_US
dc.subjectsomascan technologyen_US
dc.subjectenrichment analysisen_US
dc.subjectmean arterial pressureen_US
dc.subjectmacromoleculesen_US
dc.titleIdentification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicineen_US
dc.typeJournal Articleen_US
dcterms.available2025-02-12en_US
mel.impact-factor3.3en_US

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