Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia

cg.contactelena.ciani@uniba.iten_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerUniversity of Nottingham - UoN UKen_US
cg.contributor.centerSultan Qaboos University - Oman - SQUen_US
cg.contributor.centerKing Faisal University - KFUen_US
cg.contributor.centerConsiglio per la Ricerca e la Sperimentazione in Agricoltura / Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria - CRA / CREAen_US
cg.contributor.centerUniversity of Palermo - unipaen_US
cg.contributor.centerUniversity of Blida - USDBen_US
cg.contributor.centerKuwait University, Faculty of Scienceen_US
cg.contributor.centerUniversity of Nottingham, School of Life Sciences - UoN UK - School of Life Sciencesen_US
cg.contributor.centerUniversity of Molise - UNIMOLen_US
cg.contributor.centerUniversity of Bari Aldo Moro - UniBaen_US
cg.contributor.centerMisurata University, Faculty of Sciencesen_US
cg.contributor.centerUniversity of Limoges - UNILIMen_US
cg.contributor.centerUniversity of Blida, Science Veterinary Institute - USDB - SVIen_US
cg.contributor.crpCGIAR Research Program on Livestock Agri-Food Systems - Livestocken_US
cg.contributor.funderInternational Livestock Research Institute - ILRIen_US
cg.contributor.projectCGIAR Research Program on Livestock Agri-Food Systemsen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.countryDZen_US
cg.coverage.countryETen_US
cg.coverage.countryITen_US
cg.coverage.regionNorthern Africaen_US
cg.coverage.regionEastern Africaen_US
cg.coverage.regionSouthern Europeen_US
cg.creator.idMwacharo, Joram: 0000-0001-6981-8140en_US
cg.creator.idHanotte, Olivier: 0000-0002-2877-4767en_US
cg.identifier.doihttps://dx.doi.org/10.1371/journal.pone.0209632en_US
cg.isijournalISI Journalen_US
cg.issn1932-6203en_US
cg.issue6en_US
cg.journalPLoS ONEen_US
cg.subject.agrovocsheepen_US
cg.subject.agrovocfatsen_US
cg.subject.agrovocgenomic signal processingen_US
cg.volume14en_US
dc.contributorBahbahani, Hussainen_US
dc.contributorMoioli, Biancaen_US
dc.contributorAhbara, Abugasimen_US
dc.contributorAli Al Abri, Mohammeden_US
dc.contributorAlmathen, Faisalen_US
dc.contributorSilva, Anne daen_US
dc.contributorBelabdi, Ibrahimen_US
dc.contributorPortolano, Baldassareen_US
dc.contributorMwacharo, Joramen_US
dc.contributorHanotte, Olivieren_US
dc.contributorPilla, Fabioen_US
dc.contributorCiani, Elenaen_US
dc.creatorMastrangelo, Salvatoreen_US
dc.date.accessioned2020-03-02T17:09:51Z
dc.date.available2020-03-02T17:09:51Z
dc.description.abstractGenomic regions subjected to selection frequently show signatures such as within-population reduced nucleotide diversity and outlier values of differentiation among differentially selected populations. In this study, we analyzed 50K SNP genotype data of 373 animals belonging to 23 sheep breeds of different geographic origins using the Rsb (extended haplotype homozygosity) and FST statistical approaches, to identify loci associated with the fattail phenotype. We also checked if these putative selection signatures overlapped with regions of high-homozygosity (ROH). The analyses identified novel signals and confirmed the presence of selection signature in genomic regions that harbor candidate genes known to affect fat deposition. Several genomic regions that frequently appeared in ROH were also identified within each breed, but only two ROH islands overlapped with the putative selection signatures. The results reported herein provide the most complete genome-wide study of selection signatures for fat-tail in African and Eurasian sheep breeds; they also contribute insights into the genetic basis for the fat tail phenotype in sheep, and confirm the great complexity of the mechanisms that underlie quantitative traits, such as the fat-tail.en_US
dc.formatPDFen_US
dc.identifierhttps://mel.cgiar.org/reporting/downloadmelspace/hash/9ad8ef8a15e72da17f6a6c9897477099/v/e5f4fb5a36b4d39cb4d991406a8c423een_US
dc.identifier.citationSalvatore Mastrangelo, Hussain Bahbahani, Bianca Moioli, Abugasim Ahbara, Mohammed Ali Al Abri, Faisal Almathen, Anne da Silva, Ibrahim Belabdi, Baldassare Portolano, Joram Mwacharo, Olivier Hanotte, Fabio Pilla, Elena Ciani. (14/6/2019). Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia. PLoS ONE, 14 (6).en_US
dc.identifier.statusOpen accessen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/10869
dc.languageenen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsCC-BY-4.0en_US
dc.sourcePLoS ONE;14,(2019)en_US
dc.subjectgenomic regionen_US
dc.titleNovel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasiaen_US
dc.typeJournal Articleen_US
dcterms.available2019-06-14en_US
mel.impact-factor2.776en_US
mel.project.openhttps://mel.cgiar.org/projects/237en_US

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