Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia
cg.contact | elena.ciani@uniba.it | en_US |
cg.contributor.center | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.contributor.center | University of Nottingham - UoN UK | en_US |
cg.contributor.center | Sultan Qaboos University - Oman - SQU | en_US |
cg.contributor.center | King Faisal University - KFU | en_US |
cg.contributor.center | Consiglio per la Ricerca e la Sperimentazione in Agricoltura / Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria - CRA / CREA | en_US |
cg.contributor.center | University of Palermo - unipa | en_US |
cg.contributor.center | University of Blida - USDB | en_US |
cg.contributor.center | Kuwait University, Faculty of Science | en_US |
cg.contributor.center | University of Nottingham, School of Life Sciences - UoN UK - School of Life Sciences | en_US |
cg.contributor.center | University of Molise - UNIMOL | en_US |
cg.contributor.center | University of Bari Aldo Moro - UniBa | en_US |
cg.contributor.center | Misurata University, Faculty of Sciences | en_US |
cg.contributor.center | University of Limoges - UNILIM | en_US |
cg.contributor.center | University of Blida, Science Veterinary Institute - USDB - SVI | en_US |
cg.contributor.crp | CGIAR Research Program on Livestock Agri-Food Systems - Livestock | en_US |
cg.contributor.funder | International Livestock Research Institute - ILRI | en_US |
cg.contributor.project | CGIAR Research Program on Livestock Agri-Food Systems | en_US |
cg.contributor.project-lead-institute | International Center for Agricultural Research in the Dry Areas - ICARDA | en_US |
cg.coverage.country | DZ | en_US |
cg.coverage.country | ET | en_US |
cg.coverage.country | IT | en_US |
cg.coverage.region | Northern Africa | en_US |
cg.coverage.region | Eastern Africa | en_US |
cg.coverage.region | Southern Europe | en_US |
cg.creator.id | Mwacharo, Joram: 0000-0001-6981-8140 | en_US |
cg.creator.id | Hanotte, Olivier: 0000-0002-2877-4767 | en_US |
cg.identifier.doi | https://dx.doi.org/10.1371/journal.pone.0209632 | en_US |
cg.isijournal | ISI Journal | en_US |
cg.issn | 1932-6203 | en_US |
cg.issue | 6 | en_US |
cg.journal | PLoS ONE | en_US |
cg.subject.agrovoc | sheep | en_US |
cg.subject.agrovoc | fats | en_US |
cg.subject.agrovoc | genomic signal processing | en_US |
cg.volume | 14 | en_US |
dc.contributor | Bahbahani, Hussain | en_US |
dc.contributor | Moioli, Bianca | en_US |
dc.contributor | Ahbara, Abugasim | en_US |
dc.contributor | Ali Al Abri, Mohammed | en_US |
dc.contributor | Almathen, Faisal | en_US |
dc.contributor | Silva, Anne da | en_US |
dc.contributor | Belabdi, Ibrahim | en_US |
dc.contributor | Portolano, Baldassare | en_US |
dc.contributor | Mwacharo, Joram | en_US |
dc.contributor | Hanotte, Olivier | en_US |
dc.contributor | Pilla, Fabio | en_US |
dc.contributor | Ciani, Elena | en_US |
dc.creator | Mastrangelo, Salvatore | en_US |
dc.date.accessioned | 2020-03-02T17:09:51Z | |
dc.date.available | 2020-03-02T17:09:51Z | |
dc.description.abstract | Genomic regions subjected to selection frequently show signatures such as within-population reduced nucleotide diversity and outlier values of differentiation among differentially selected populations. In this study, we analyzed 50K SNP genotype data of 373 animals belonging to 23 sheep breeds of different geographic origins using the Rsb (extended haplotype homozygosity) and FST statistical approaches, to identify loci associated with the fattail phenotype. We also checked if these putative selection signatures overlapped with regions of high-homozygosity (ROH). The analyses identified novel signals and confirmed the presence of selection signature in genomic regions that harbor candidate genes known to affect fat deposition. Several genomic regions that frequently appeared in ROH were also identified within each breed, but only two ROH islands overlapped with the putative selection signatures. The results reported herein provide the most complete genome-wide study of selection signatures for fat-tail in African and Eurasian sheep breeds; they also contribute insights into the genetic basis for the fat tail phenotype in sheep, and confirm the great complexity of the mechanisms that underlie quantitative traits, such as the fat-tail. | en_US |
dc.format | en_US | |
dc.identifier | https://mel.cgiar.org/reporting/downloadmelspace/hash/9ad8ef8a15e72da17f6a6c9897477099/v/e5f4fb5a36b4d39cb4d991406a8c423e | en_US |
dc.identifier.citation | Salvatore Mastrangelo, Hussain Bahbahani, Bianca Moioli, Abugasim Ahbara, Mohammed Ali Al Abri, Faisal Almathen, Anne da Silva, Ibrahim Belabdi, Baldassare Portolano, Joram Mwacharo, Olivier Hanotte, Fabio Pilla, Elena Ciani. (14/6/2019). Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia. PLoS ONE, 14 (6). | en_US |
dc.identifier.status | Open access | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.11766/10869 | |
dc.language | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | CC-BY-4.0 | en_US |
dc.source | PLoS ONE;14,(2019) | en_US |
dc.subject | genomic region | en_US |
dc.title | Novel and known signals of selection for fat deposition in domestic sheep breeds from Africa and Eurasia | en_US |
dc.type | Journal Article | en_US |
dcterms.available | 2019-06-14 | en_US |
mel.impact-factor | 2.776 | en_US |
mel.project.open | https://mel.cgiar.org/projects/237 | en_US |